Zolpidem and triazolam do not affect the nocturnal sleep-induced memory improvement |
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Authors: | Jaime?Meléndez Irina?Galli Katica?Boric Alonso?Ortega Leonardo?Zu?iga Carlos?F?Henríquez-Roldán Email author" target="_blank">Ana?M?CárdenasEmail author |
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Institution: | Escuela de Psicología, Universidad de Valparaíso, Valparaíso, Chile. |
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Abstract: | Rationale It is widely accepted that sleep facilitates memory consolidation. Hypnotics (e.g., benzodiazepines), which reportedly increase
sleep efficiency but also modify sleep architecture, could affect memory improvement that occurs during sleep.
Objectives The present study examined the effects of single doses of two short half-life hypnotics, zolpidem and triazolam, on sleep-induced
improvement of memory.
Methods Twenty-two healthy volunteers participated in this randomized, double-blind, crossover study. All subjects received a single
oral dose of zolpidem (10 mg), triazolam (0.25 mg) or placebo at 9 p.m. and slept for 7.5±0.2 h. The effect of sleep on memory was investigated by comparing the performance of this group of volunteers
with a group of 21 subjects in wakefulness condition. Declarative memory was evaluated by using a free-recall test of ten
standard word and seven nonword lists. Subjects memorized the word and nonword lists 1 h before dosing and they were asked
to recall the memorized lists 10 h after dosing. Digit symbol substitution test (DSST) and forward and backward digit tests
were also given 1 h before and 10 h after dosing.
Results Subjects who slept remembered more nonwords than those in wakefulness condition, but they did not recall significantly more
standard words. Neither zolpidem nor triazolam affected the enhanced nonword recall observed after sleep. Finally, none of
the hypnotics affected the improvement in the DSST performance of subjects who slept.
Conclusions The hypnotics tested did not interfere with the nocturnal sleep-induced improvement of memory. |
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Keywords: | Zolpidem Triazolam Memory consolidation Sleep Hypnotics |
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