| 红霉素发酵培养基优化研究 |
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| 引用本文： | 张金国,刘翔.红霉素发酵培养基优化研究[J].中国抗生素杂志,2006,31(7):406-407,416. |
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| 作者姓名： | 张金国 刘翔 |
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| 作者单位： | 安阳工学院,安阳,455000 |
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| 摘 要： | 对红霉素发酵培养基进行了优化，选用A粉和B粉代替原工艺中的淀粉及部分葡萄糖和豆饼粉。采用正交试验设计方法。确定最佳发酵培养基配方，并考察了中间补料方案。经10吨发酵罐连续8批验证，平均发酵效价提高6．11％，产品质量全部合格。原材料消耗成本可降低20％以上。
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| 关 键 词： | 红霉素 发酵 培养基优化 |
| 文章编号： | 1001-8689（2006）07-0406-02 |
| 收稿时间： | 2005-12-12 |
| 修稿时间： | 2005-12-12 |
A research on the improvement of medium composition for erythromycin fermentation |
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| Zhang Jin-guo,Liu Xiang.A research on the improvement of medium composition for erythromycin fermentation[J].Chinese Journal of Antibiotics,2006,31(7):406-407,416. |
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| Authors: | Zhang Jin-guo Liu Xiang |
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| Institution: | Anyang Institute of Technology, Anyang 455000 |
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| Abstract: | An improved medium formula for erythromycin fermentation by powders A and B to replace starch and/or part of glucose and bean cake was established. The optimization of the medium was carried out by using orthogonal analytical method. The average production level of 8 successive batches in a 10-ton fermentation tank with improved medium was increased by 6. 11% and the raw material cost was reduced by 20% and the products complied with the quality standard requirements. |
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| Keywords: | Erythromycin Fermentation Medium optimization |
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