Impaired verbal memory is associated with impaired motor performance in schizophrenia: relationship to brain structure |
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Authors: | Manschreck T C Maher B A Candela S F Redmond D Yurgelun-Todd D Tsuang M |
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Affiliation: | Department of Psychiatry, Dr. John C. Corrigan Mental Health Center, 49 Hillside Street, 02720, Fall River, MA 02215, USA. theo.manschreck@dmh.state.ma.us |
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Abstract: | Deficient ability to take advantage of predictable elements in the performance of cognitive tasks has been proposed as an underlying factor for a number of deviances in schizophrenia. In a schizophrenic sample (n=39), we propose and test the view that certain memory and motor anomalies arise because of a compromise in the capacity to take advantage of the redundant (predictable) features of cognitive tasks. Results demonstrate a relationship between reduced capacity to take advantage of predictable features of two different cognitive processing tasks, one verbal memory, and the other motor. Poorer verbal recall on high-redundancy word lists was associated with a reduced ability to produce synchronous finger tapping in response to a high redundancy auditory stimulus, and inversely correlated with formal thought disorder ratings. These relationships, we suggest, reflect a specific and common schizophrenic deficit in the use of redundancies, not attributable to a generalized deficiency in performance. Structural imaging evidence from a subsample of these subjects (n=16) implicates frontal areas as the locus of this cognitive impairment. |
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