Expression of NAD(P)H: quinone oxidoreductase and glutathione S-transferases {alpha} and {pi} in human renal cell carcinoma and in kidney cancer-derived cell lines |
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| Authors: | Eickelmann, Peter Ebert, Thomas Warskulat, Ulrich Schulz, Wolfgang A. Sies, Helmut |
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| Affiliation: | Institut fur Physiologische Chemie Postfach 10 10 07, D-40001 Dusseldorf, Germany
1Urologische Klinik, Heinrich-Heine-Universität Düsseldorf Postfach 10 10 07, D-40001 Dul.ubar;sseldorf, Germany |
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| Abstract: | NAD(P)H:quinone oxidoreductase (NQOR) and glutathione S-transferases(GST) are enzymes of interest in cell defence and drug resistance.Relative levels of NQOR mRNA in renal cell carcinomas were 28±24% (n=21) of those in non-neoplastic tissue and theenzyme activity decreased from 41±39 to 18±27mU/mg protein (n=23). In three of the cases, there was no measurableNQOR enzyme activity at all, indicating a polymorphism in thepopulation for this gene. Relative GST-a mRNA levels in thetumours were on average 6±6% (n=22) of the control value,whereas for GST- |
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