| 降钙素基因相关肽对高血压性与运动性心肌肥厚影响的对比研究 |
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| 引用本文： | 李春跃,韩补生,南瑞生.降钙素基因相关肽对高血压性与运动性心肌肥厚影响的对比研究[J].内蒙古医学院学报,2001,23(2):79-81. |
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| 作者姓名： | 李春跃 韩补生 南瑞生 |
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| 作者单位： | 内蒙古医学院生理教研室,内蒙古,呼和浩特,010059 |
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| 基金项目： | 内蒙古自然科学基金资助项目 号 :980 91 |
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| 摘 要： | 目的：探讨高血压性与运动性心肌肥厚的产生机制的差异。方法：以缩窄大鼠的腹主动脉加盐负荷制作高血压性心肌肥厚，以游泳运动制作运动性心肌肥厚模型，用特异性放射免疫测定技术，检测心肌组织和血浆中降钙素基因相关肽（CGRP）的含量。结果：高血压组大鼠心肌组织和血浆中CGRP含量显著低于运动组和对照组（P＜0．05）。结论：CGRP可能在降低心肌肥厚程度中具有一定作用，并有利于肥厚心肌血液供应，使心肌收缩功能增强。
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| 关 键 词： | 心肌肥厚 高血压 运动 降钙素基因相关肽 |
| 文章编号： | 1004-2113(2001)02-0079-03 |
| 修稿时间： | 2001年2月21日 |
CONTRAST STUDY OF CALCITONIN GENE RELATED PEPTIDE INFLUENCING THE HYPERTENSIVE AND EXERCISED MYOCARDIAL HYPERTROPHY |
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| LI Chun-yue,HAN Bu-sheng,NAN Rui-sheng.CONTRAST STUDY OF CALCITONIN GENE RELATED PEPTIDE INFLUENCING THE HYPERTENSIVE AND EXERCISED MYOCARDIAL HYPERTROPHY[J].Acta Academiae Medicinae Neimongol,2001,23(2):79-81. |
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| Authors: | LI Chun-yue HAN Bu-sheng NAN Rui-sheng |
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| Abstract: | Objective:To investigate the differences in developing mechanism between hypertensive myocardial hypertrophy and exercised myocardial hypertrophy. Methods:The model of hypertensive myocardial hypertrophy was made by constricting abdominal aorta of rats and feeding salt, and exercised myocardial hypertrophy by swimming exercises. Specific radioimmunoassay was applied to test the content of CGRP in myocardium and plasma. Results:The content of CGRP in both myocardium and plasma in hypertensive group is significantly lower than tnat in exercise group and control group (P<0 05). Conclusion:CGRP has relation to the development of myocardial hypertrophy. CGRP can reduce hypertrophy degree of myocardium, and improve blood supply of hypertrophic myocardium and enhance contracting function of myocardium. |
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| Keywords: | myocardial hypertrophy hypertension exercise CGRP |
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