The effect of oral contraceptives on current wheezing in young women |
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| Authors: | M Erkoçoğlu A Kaya D Azkur Ş Özyer C Özcan M Beşli E Civelek CN Kocabaş |
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| Institution: | 1. Ankara Children''s Hematology Oncology Education and Research Hospital, Department of Pediatric Allergy, Ankara, Turkey;2. Ankara Zekai Tahir Burak Women''s Health, Education and Research Hospital, Ankara, Turkey;1. Ankara University, School of Medicine, Department of Pulmonary Disease, Division of Immunology and Allergy, Ankara, Turkey;2. Ankara University, School of Medicine, Department of PM&R, Division of Rheumatology, Ankara, Turkey;3. Harvard Medical School, Adverse Drug Reaction and Desensitization Program, Allergy and Immunology Training Program, Brigham and Women''s Hospital, Boston, MA, USA;2. Section of Allergology and Clinical Immunology, Department of Internal Medicine and Infectious Diseases, University of Bari Medical School, Bari, Italy;3. Section of Allergology and Clinical Immunology, Unit of Internal Medicine, “F. Miulli” Hospital, Acquaviva delle Fonti, Bari, Italy;4. Allergy and Clinical Immunology Center, Civil Hospital Vito Fazzi, Lecce, Italy;5. Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy;1. Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”-Trieste, Universisty of Trieste, Italy;2. Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”-Trieste, Italy;1. Department of Paediatrics, Catholic University, Rome, Italy;2. Department of Paediatrics, San Camillo Hospital, Rome, Italy;3. Lofarma SpA, Milano, Italy |
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| Abstract: | BackgroundEmerging evidence suggests that sex steroid hormones may influence respiratory symptoms. The existing literature about the role of oral contraceptive pill (OCP) on respiratory disease is scarce and conflicting especially during the adolescent period. In this study, we aimed to investigate the effect of OCPs on current wheezing among adolescents and young adults.MethodsA questionnaire was administered face-to-face to adolescents and young women by a physician. The questionnaire included ISAAC survey-comprised questions on ever wheezing, current wheezing, allergic diseases, smoking history (active or passive), and family history of allergic diseases and questions on OCP usage status. The effect of OCPs on wheezing was evaluated by logistic regression analysis.ResultsA total of 487 subjects aged between 11.3 and 25.6 years participated in the study and 196 (40.2%) reported that they had used OCPs. 7.4% of the participants had physician-diagnosed asthma and 10.3% of them were active smokers. It was detected that OCPs were associated with increased risk for current wheezing (odds ratio, 2.36; 95% CI, 1.25–4.47 adjusted for asthma and current smoker) and this risk was related with the usage during the past year.ConclusionYoung women taking oral contraceptives had a higher rate of current wheezing, suggesting that sex steroids may be of importance for respiratory health. |
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