活体共聚焦显微镜下睑板腺囊肿患者睑板腺形态分析

目的:分析睑板腺囊肿患者的睑板腺组织在活体共聚焦显微镜(IVCM)下的形态学改变及特点。方法:采用横断面研究方法，选取2018年9月至2019年4月在汕头大学·香港中文大学联合汕头国际眼科中心就诊的睑板腺囊肿患者34例34眼以及无睑板腺疾病患者18例18眼分别作为睑板腺囊肿组和对照组。对所有受检者进行眼科常规检查及IV...

Morphological analysis of meibomian glands in patients with meibomian gland cyst under in vivo confocal microscope

Objective To analyze the morphological changes and features of meibomian gland in patients with meibomian gland cyst under in vivo confocal microscope(IVCM).Methods A cross-sectional study was performed.A total of 34 patients(34 eyes)with meibomian gland cysts and 18 control subjects(18 eyes)in the outpatient department without meibomian gland cysts treated in Shantou International Eye Center from September 2018 to April 2019 were included into the meibomian gland cyst group and control group accordingly.All the subjects underwent routine ophthalmologic examination and IVCM examination.IVCM test indicators included the opening area of meibomian gland,the longest diameter and the shortest diameter of meibomian gland opening,the morphology of glandular tube and acinus adjacent to the meibomian gland opening.The measurement indexes of the meibomian gland cyst group and the control group were compared and analyzed.This study followed the Declaration of Helsinki and was approved by the Ethics Committee of Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong(No.EC20171103[6]-P01).Written informed consent was obtained from each patient before examination.Results The opening of the meibomian glands of the 34 subjects in the meibomian gland cyst group were all enlarged irregularly with smooth boundaries,and emboli in the openings were observed in 70.59%(24/34)of patients.The longest diameter,the shortest diameter and the area of meibomian gland openings were(148.12±70.16)μm,(114.77±52.38)μm and 9239.11(5506.96,24111.36)μm2 in the meibomian gland cyst group,respectively,while(59.35±16.78)μm,(41.98±11.77)μm and 2094.19(1432.28,2945.65)μm2 in the control group,respectively.Compared with the control group,the longest diameter and shortest diameter in the meibomian cyst group were longer,and the area of meibomian gland openings in the meibomian cyst group was larger,and the differences were statistically significant(all at P<0.01).Adjacent to the opening,there was cystic dilation of glandular tube containing accumulated secretion of different characteristics detected in the 61.76%(21/34)of patients in the meibomian gland cyst group,and the dilated glandular tubes were with flat edges.The boundaries between the dilated glandular tubes and surrounding acini were clear.Conclusions In vivo confocal microscope can detect the morphological changes of meibomian glands in patients with meibomian gland cyst,including enlarged opening with embolus,cystic dilation of glandular tube with clear boundary and accumulated secretion.