The long-term outcomes of persistent childhood allergic asthma: A cross-sectional study from western Anatolia: Childhood persistent asthma in western Anatolia |
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| Authors: | Ö Bağ D Can U Karaarslan İ Günay CŞ Turgut HT Nacaroğlu |
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| Institution: | 1. Clinics of Pediatrics, Dr. Behçet Uz Children''s Teaching and Research Hospital, Izmir, Turkey;2. Clinics of Pediatric Allergy and Immunology, Dr. Behçet Uz Children''s Teaching and Research Hospital, Izmir, Turkey;1. Department of Paediatrics, Catholic University, Rome, Italy;2. Institute for Maternal and Child Health, IRCCS Burlo Garofolo, University of Trieste, Italy;3. Department of Pediatrics, San Camillo de Lellis Hospital, Rome, Italy;1. Greater Los Angeles VA Health Care System, Los Angeles, CA, USA;2. Professor Emeritus UCLA School of Medicine, Los Angeles, CA, USA;1. Pediatric Pulmonology and Allergy Unit, Istituto Giannina Gaslini, Genoa, Italy;2. Pediatric Clinic, University of Genoa – Istituto Giannini Gaslini, Genoa, Italy;3. Allergy and Respiratory Diseases Clinic, IRCCS – Azienda Ospedaliera Universitaria San Martino, Genoa, Italy;1. Dokuz Eylul University Medical Faculty, Department of Pulmonary Diseases, Izmir, Turkey;2. Dokuz Eylul University Medical Faculty, Department of Biochemistry, Izmir, Turkey;3. Dokuz Eylul University Medical Faculty, Department of Biostatistics and Medical Informatics, Izmir, Turkey;1. Allergy Unit, A. Meyer Children Hospital, Department of Pediatrics, Florence, Italy;2. Department of Pharmacological Sciences, State University of Milan, Milan, Italy |
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| Abstract: | BackgroundProspective cohort studies have provided useful knowledge about the natural history of asthma. However, most of the studies are conducted in western countries but the course of the disease and long-term outcomes may differ between countries due to environmental and cultural factors.ObjectiveThe aim of this study is to describe the long-term outcomes of childhood asthma, with data from a follow-up study of at least 10 years, in western Anatolia, Turkey.MethodsFifty-two patients diagnosed with persistent allergic asthma participated in the study. The patient's demographics, findings on admission, age at onset of disease, time of diagnosis, history of other allergic conditions, history of parental asthma and allergic disorders, presence of pharmacotherapy and immunotherapy were obtained from patients’ records. The factors influencing remission at the end of 10 years follow-up were evaluated.ResultsA total of 20 patients (38.5%) were on remission at the end of 10 years. The type of allergen, multi-allergen sensitivity, eosinophilia and elevated serum immunoglobulin E on admission, accompanying allergic disorders and atopy in parents, and allergen immunotherapy did not affect the remission rate (p > 0.05).ConclusionChildhood persistent asthma is not a homogeneous clinical entity but high clinical remission rates are obtained in western Anatolia. There is no significant predictor of clinical remission in long term follow-up. Prospective studies should be performed in larger asthmatic populations to obtain further data about the natural course of childhood asthma. |
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