肥胖型和非肥胖型PCOS患者血清中GLP-1变化水平及其与BMI、激素水平相关性研究

目的 研究肥胖型和非肥胖型多囊卵巢综合征(PCOS)患者空腹血浆胰高血糖素样肽1(GLP-1)的分泌水平并评估其与体重指数(BMI)、激素间的相关性.方法 选取34例PCOS患者为PCOS组,16例正常健康妇女为对照组,根据BMI将PCOS组分为肥胖型PCOS患者和非肥胖型PCOS患者,采用酶联免疫法检测空腹血清GLP...

Study on the changes of serum GLP-1 in obese and non-obese patients with polycystic ovary syndrome and its correlation with body mass index and hormone levels

Objective To study the level of fasting plasma glucagon-like peptide 1(GLP-1)in obese and non-obese patients with polycystic ovary syndrome(PCOS)and evaluate its correlation with body mass index(BMI)and hormone levels.Methods Totally 34 patients with PCOS were enrolled as PCOS group and 16 healthy women were enrolled as control group.The patients in PCOS group were divided into obese PCOS group and non-obese PCOS group according to BMI.Fasting serum GLP-1 level,fasting plasma glucose,fasting insulin,sex hormones and lipid metabolism were measured.Pearson correlation test was used to analyze the correlation between GLP-1 level and BMI and hormones.Results The levels of serum GLP-1,T,LH,LH/FSH,free androgen index(FAI),DHEAS,LDL-C and HOMA-IR in PCOS group were significantly higher than those in control group(t=3.21,6.10,4.79,4.35,5.24,3.82,2.69,2.71,P<0.05),while the level of SHBG was significantly lower than that in control group(t=-5.64,P<0.05).The serum levels of LH,LH/FSH,SHBG and HDL-C in obese PCOS group were significantly lower than those in non-obese PCOS group(t=-0.31,-2.44,-2.35,-2.70,P<0.05),while the levels of GLP-1,FAI,TC,TG,LDL-C and HOMA-IR in obese PCOS group were significantly higher than those in non-obese PCOS group(t=2.36,3.18,1.83,4.43,3.41,2.62,P<0.05).The results of correlation analysis showed that the level of GLP-1 was correlated with BMI and LH/FSH(r=0.38,-0.34,P<0.05).Conclusion The hormone level and glucose and lipid metabolism of PCOS patients are abnormal,and there are some differences among different types of PCOS patients.Compared with non-obese PCOS patients,obese PCOS patients are more likely to develop glucose and lipid metabolism disorders,and their serum GLP-1 concentration is significantly higher,GLP-1 may be involved in the regulation of hormone levels and lipid metabolism in obese PCOS patients.