老年EH伴HF-PEF患者血浆NT-proBNP、E/A及LVMI值的变化及其诊断价值

目的 探讨老年原发性高血压(EH)射血分数保留的心力衰竭(HF-PEF)患者血浆氨基末端脑钠肽前体(NT-proBNP)、二尖瓣口舒张早期最大血流峰值(E峰)/二尖瓣心房收缩期最大血流峰值(A峰)、左心室质量指数(LVMI)的变化及其意义.方法 选取2017年3月～2019年5月确诊的老年EH伴HF-PEF患者90例作...

Changes of plasma NT-proBNP,E/A and LVMI in elderly patients with EH and HF-PEF and their diagnostic value

Objective To investigate the changes of plasma N-terminal pro-brain natriuretic peptide(NT-proBNP),maximal peak blood flow in early diastole of mitral valve(peak E)(peak E)/maximal peak blood flow during mitral atrial systole(peak A)and left ventricular mass index(LVMI)in elderly patients with essential hypertension(EH)and heart failure with preserved ejection fraction(HF-PEF)and their significance.Methods 90 elderly EH patients with HF-PEF diagnosed from March 2017 to May 2019 were selected as HF-PEF group,and 90 simple EH patients were selected as EH group.The plasma NT-proBNP level was detected by ELISA,and the left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),E/A and LVMI were measured by echocardiography.Receiver operating curve(ROC)was used to analyze the value of NT-proBNP,E/A and LVMI in the differential diagnosis of HF-PEF in EH patients.Results The plasma NT-proBNP level of HF-PEF group was significantly higher than that of EH group,E/A value was lower than that of EH group,LVMI was larger than that of EH group.The above differences between the two groups were statistically significant(P<0.05).But there was no significant difference in LVEF and LVEDD between the two groups(P>0.05).ROC curve analysis results showed that the sensitivity of plasma NT-proBNP in differential diagnosis of EH with HF-PEF was 88.20%,the specificity was 97.21%,the AUC value under ROC curve was 0.940;the sensitivity of E/A value in differential diagnosis of EH with HF-PEF was 85.41%,the specificity was 94.39%,and the AUC value under the ROC curve was 0.922;the sensitivity of LV differential diagnosis of EHMI with HF-PEF was 74.90%,the specificity was 88.17%,and the AUC value under the ROC curve was 0.827.Conclusion The NT-proBNP and LVMI increased and E/A decreased in elderly EH patients with HF-PEF.The detection of the above three indexes has a certain value in the diagnosis of HF-PEF.