宫腔镜电切术联合米非司酮治疗子宫内膜增生症疗效观察

目的观察宫腔镜下子宫内膜电切术（TCRE）后联合米非司酮治疗子宫内膜增生症的临床疗效。方法选择2008年10月～2010年8月我院宫腔镜及病理确诊为子宫内膜单纯性增生过长的患者58例行TCRE术,术后随机分为2组：单纯TCRE组（对照组）29例,术后无任何治疗;TCRE联合米非司酮组（观察组）29例,术后口服米非司酮片,10mg/d,共3个月。术后6月观察两组子宫内膜厚度、月经量、经期、血红蛋白情况。结果 TCRE联合米非司酮组子宫内膜厚度、月经量、经期时间均较单纯TCRE组减少,差异有统计学意义（P〈0.05或P〈0.01）,两组血红蛋白含量无显著差异（P〉0.05）。结论子宫内膜电切术后口服米非司酮可抑制残留子宫内膜,降低子宫内膜增生症的复发率。

Observation on effect of TCRE and mifepristone combining treatment in endometrial hyperplasia

Objective To study effect of TCRE and mifepristone combining treatment in endometrial hyperplasia,comparing with TCRE only.Methods 58 cases of endometrial hyperplasia were randomly devided into two groups.Control group：29 cases were treated by TCRE only.Observe group：29 cases were treated by TCRE combing mifepristone.The menstrual blood loss,hemoglobin and the thickness of endomtrium were observed at 6 months after TCRE.Results Compared with control group,the menstrual blood loss and the thickness of endomtrium reduced significantly（P〈0.05 or P〈0.01）.No significant difference in emoglobin between two groups（P〈0.05）.TCRE combing mifepristone was more effective than TCRE only.Conclusion It is significant to reduce reccurence rate of endometrial hyperplasia by given mifepristone after TCRE.