药物性肝损伤临床相关因素分析

目的探讨190例药物性肝损伤病例的病因、临床特点及预后相关因素，以指导临床诊断和治疗。方法对我院2006年1月-2010年12月190例药物性肝损伤住院病例进行回顾性研究，分析其用药、临床表现和预后转归情况。结果引起药物性肝损伤的药物品种繁多，其中抗肿瘤药占首位56例（29．4％），中药50例（26．3％）；临床分型以肝细胞型为主152例（80．0％），胆汁淤积型24例（12．6％）；临床表现无明显特异性，其中无任何临床表现者84例（44．2％），有明显黄疸者48例（25.3％）；经治疗后治愈30例（15．8％），好转150例（78．9％），死亡0例，10例失访。结论近年来药物性肝损伤呈明显增加趋势，以抗肿瘤药及中药为主，一般预后较好。

Retrospective analysis of drug-induced liver injury

Objective To investigate the cause, clinical features, and prognosis of drug-induced liver injury. Methods Retrospectively analyzed the clinical data of 190 patients with drug-induced liver injury in our hospital from Jan 2006 to Dec 2010. Results A variety of drugs could cause liver injury. In the 190 cases, 29.4% were induced by antineoplastic drugs, 26.3% by Chinese herbal medicines; among those patients the rate of hepatocellular damage type was 80.0% ,cholestatic damage type was 12.6%. 84 cases （44.2%） never had any abnormal manifestation, 48 cases （25.3%） presented with obvious jaundice. Tilt discharged from our hospital, 30 cases （15.8%） recovered completely, 150 cases （78.9%） got better, and no one was dead. Conclusion The incidences of drug-induced liver injury tend to ascend these years, which are mainly caused by antineoplastic drugs and Chinese herbal medicines with a tolerated prognosis.