Vancomycin prevents polytetrafluoroethylene graft infections in pediatric patients receiving chronic hemodialysis |
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| Authors: | B A Fivush G H Bock P C Guzzetta J R Salcedo E J Ruley |
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| Affiliation: | From the Departments of Nephrology and Surgery, Children''s Hospital and National Medical Center, and the Department of Child Health and Development, George Washington University School of Medicine, Washington, DC. |
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| Abstract: | Polytetrafluoroethylene (PTFE) grafts have been a useful addition to the pediatric hemodialysis vascular access armamentarium. In this study, 17 pediatric patients underwent 331 total months of hemodialysis via PTFE grafts. There was a statistically significant (P less than .025) decrease in the incidence of graft infections in 12 patients (235 patient-months) while receiving prophylactic parenteral vancomycin compared with 9 patients (96 patient-months) while receiving no vancomycin (0% v 44%). Vancomycin side effects were uncommon and mild. Vancomycin is a safe and effective agent for the prevention of PTFE graft infections in pediatric patients receiving chronic hemodialysis. |
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| Keywords: | Hemodialysis vancomycin PTFE grafts |
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