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| 倍氯米松对变应性鼻炎鼻分泌物中粒性活细胞内钙离子浓度的影响 | |
| 引用本文： | 沈志忠,王豪,王挥戈,林珏龙,陈耀文,宋德辉. 倍氯米松对变应性鼻炎鼻分泌物中粒性活细胞内钙离子浓度的影响[J]. 临床耳鼻咽喉头颈外科杂志, 2002, 16(1): 25-26 |
| 作者姓名： | 沈志忠 王豪 王挥戈 林珏龙 陈耀文 宋德辉 |
| 作者单位： | 1. 汕头大学医学院第一附属医院耳鼻咽喉科,广东汕头,515041 2. 汕头大学医学院第二附属医院耳鼻咽喉科 3. 汕头大学医学院中心实验室 |
| 基金项目： | 广东省医学科学技术研究基金资助项目(No,A1999411) |
| 摘 要： | 目的探讨倍氯米松对变应性鼻炎鼻分泌物中粒性活细胞的作用机制.方法采用激光共聚焦显微镜扫描和荧光技术,观察变应性鼻炎鼻分泌物中嗜酸性粒细胞、中性粒细胞经倍氯米松处理后细胞内钙离子浓度([Ca2+]i)的变化.结果经倍氯米松处理后,嗜酸性粒细胞、中性粒细胞[Ca2+]i明显升高.结论倍氯米松能够使嗜酸性粒细胞和中性粒细胞[Ca2+]i升高,这可能是其抗炎作用的一个重要环节. |
| 关 键 词： | 激光扫描共聚焦显微镜 倍氯米松 变应性鼻炎 嗜酸性粒细胞 钙离子 |
| 文章编号： | 1001-1781(2002)01-0025-02 |
| 修稿时间： | 2001-07-18 |
The effects of BDP on calcium ion in the granular leukocytes in nasal secretions of the patients with allergic rhinitis |
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| SHEN Zhizhong WANG Hao WANG Huige LIN Juelong CHEN Yaowen SONG Dehui. The effects of BDP on calcium ion in the granular leukocytes in nasal secretions of the patients with allergic rhinitis[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2002, 16(1): 25-26 | |
| Authors: | SHEN Zhizhong WANG Hao WANG Huige LIN Juelong CHEN Yaowen SONG Dehui |
| Affiliation: | Department of Otolaryngology, First Affiliated Hospital of Shantou University Medical College, Shantou 515041. |
| Abstract: | Objective:To study the effects of beclomethasone dipropionate (BDP) on the inflammatory granular leukocytes in nasal secretions of the patients with allergic rhinitis.Method:The change of intercellular calcium ion of the eosinophils and neutrocytes in the nasal secretions were observed under the laser scanning confocal microscopy and technology of fluorescence.Result:The concentration of intercellular calcium ion either in eosinophils or in neutrocytes significantly rose after BDP treatment.Conclusion:BDP can rise the concentration of intercellular calcium ion in the granular leukocytes,which may be a factor of the anti inflammation functions of BDP. |
| Keywords: | Laser scanning confocal microscopy Beclomethasone dipropionate Allergic rhinitis Eosinophils Calcium ion |
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