新生儿感染性肺炎γ干扰素和补体急性相蛋白的变化及其意义

探讨新生儿不同病原感染性肺炎γ-干扰素(IFN-γ)和补体急性相蛋白(C_3、C_4和B因子)的变化及其意义。采用免疫酶法(ELISA)、速率散射比浊法检测肺炎患儿血清IFN-γ、C_3、C_4、B因子(Bf)含量。以CRP≥20mg/L作为诊断细菌性感染的界限值,结合其它临床资料,将肺炎患儿分为4组进行结果分析。结果:(1)肺炎病因学检测:肺炎组111份血清中,8型常见病毒及支原体特异性IgM阳性40份(36.04％);对照组30份血清均阴性。病毒及支原体肺炎23例(20.7％),细菌性肺炎45例(40.5％),病毒及支原体合并细菌性肺炎17例(15.3％),其它肺炎26例(23.4%)。(2)IFN-γ和补体急性相蛋白含量检测:IFN-γ、C_3、C_4和Bf含量在肺炎各组与对照组之间差异无统计学意义(P>O.05)。结论:病毒及支原体、细菌、病毒及支原体合并细菌感染和其它感染为本地区新生儿肺炎的重要病因。体液中发挥非特异性免疫功能的IFN-γ、补体C_3、C_4和Bf含量不足,是新生儿容易发生感染性肺炎的原因之一。

CHANGE AND CLINICAL SIGNIFICANCE OF SERUM INTERFERON-GAMMA AND ACUTE PHASE COMPLEMENT PROTEINS IN NEWBORN INFANTS WITH INFECTIOUS PNEUMONIA

Objective To explore change and clinical significance of serum interferon-gamma (IFN -r), acute phase complement proteins (C3, c4, factor B) in newborn infants with infectious pneumonia. Methods Accordis to their special surum IgM or serum CrP, 111 infants, suffered from pneumonia, wese divided into 4 groups, vivus or mycoplasma infeition(n = 23) , bacteria infection(n = 45) , mixed infection of vivus or mycoplasma with bacteria (n = 17), and miscellanious pneumonia (n = 26) . IFN - r and acute phase complement proteins, including C3,C4, factor B, were detected in and 30 control infants. Results There were no difference of serum concentration of IFN - r,C3 ,C4, factor B between pneumonia group and control, and among variant types pneumonia groups and the control. Conclusion virus' and mycoplasma and bacteria, are common of pathogens of "neonatal pneumonia in our area. Low serum concertration of IFN - r, C3, C4 , factor B in newborn infants contribute to the susceptibility of ne-onates to infectious pneumonia.