Expanding role of 18F-fluoro-d-deoxyglucose PET and PET/CT in spinal infections |
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Authors: | Filip Gemmel Paul C. Rijk James M. P. Collins Thierry Parlevliet Katrin D. Stumpe Christopher J. Palestro |
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Affiliation: | (1) Department of Nuclear Medicine, KCL, Medical Center Leeuwarden, Borniastraat 34, 8934 AD Leeuwarden, The Netherlands;(2) Department of Orthopaedic Surgery, Medical Center Leeuwarden, Leeuwarden, The Netherlands;(3) Department of Radiology, Medical Center Leeuwarden, Leeuwarden, The Netherlands;(4) Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium;(5) Division of Nuclear Medicine, Department of Medical Radiology, University Hospital Zurich, Zurich, Switzerland;(6) Division of Nuclear Medicine and Molecular Imaging, North Shore-Long Island Jewish Health System, New Hyde Park, Manhasset, NY, USA |
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Abstract: | 18F-fluoro-d-deoxyglucose positron emission tomography ([18F]-FDG PET) is successfully employed as a molecular imaging technique in oncology, and has become a promising imaging modality in the field of infection. The non-invasive diagnosis of spinal infections (SI) has been a challenge for physicians for many years. Morphological imaging modalities such as conventional radiography, computed tomography (CT), and magnetic resonance imaging (MRI) are techniques frequently used in patients with SI. However, these methods are sometimes non-specific, and difficulties in differentiating infectious from degenerative end-plate abnormalities or postoperative changes can occur. Moreover, in contrast to CT and MRI, FDG uptake in PET is not hampered by metallic implant-associated artifacts. Conventional radionuclide imaging tests, such as bone scintigraphy, labeled leukocyte, and gallium scanning, suffer from relatively poor spatial resolution and lack sensitivity, specificity, or both. Initial data show that [18F]-FDG PET is an emerging imaging technique for diagnosing SI. [18F]-FDG PET appears to be especially helpful in those cases in which MRI cannot be performed or is non-diagnostic, and as an adjunct in patients in whom the diagnosis is inconclusive. The article reviews the currently available literature on [18F]-FDG PET and PET/CT in the diagnosis of SI. |
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Keywords: | Spinal infection MRI SPECT PET [18F]-FDG |
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