Hydroxyespintanol and schefflerichalcone: two new compounds from <Emphasis Type="Italic">Uvaria scheffleri</Emphasis> |
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| Authors: | Momoyo Ichimaru Noriyoshi Nakatani Masataka Moriyasu Yumi Nishiyama Atsushi Kato Simon G Mathenge Francis D Juma Patrick B ChaloMutiso |
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| Institution: | (1) Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan;(2) Department of Natural Medicinal Chemistry, University of Nairobi, P.O. Box 30197, Nairobi, Kenya;(3) Department of Medicine, University of Nairobi, P.O. Box 30588, Nairobi, Kenya; |
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| Abstract: | A chemical investigation of the petroleum ether extract and chloroform extract of the root of Uvaria scheffleri Diels (Annonaceae) led to the isolation of two new compounds, named hydroxyespintanol (1) and schefflerichalcone (2), together with eight known compounds (3–10). The structural elucidation of compounds 1 and 2 by spectroscopic studies is described. The cytotoxicity of the isolated compounds against human promyelocytic leukemia HL-60
cells was studied. Among these, 2′-hydroxy-3′,4′,6′-trimethoxychalcone (5) exhibited cytotoxicity (IC50 12 μM), and espintanol (3), which was the main ingredient, also showed some cytotoxicity (IC50 44 μM). |
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