| 酪氨酸激酶受体EphA5及其配体ephrin-A5在小鼠脊髓发育过程中的表达(英文) |
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| 引用本文： | Christopher P.WASHBURN,Margaret A.COOPER,周仁平. 酪氨酸激酶受体EphA5及其配体ephrin-A5在小鼠脊髓发育过程中的表达(英文)[J]. 中国神经科学杂志, 2007, 0(5) |
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| 作者姓名： | Christopher P.WASHBURN Margaret A.COOPER 周仁平 |
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| 作者单位： | 岁格斯新洋西州立大学Ernest Mario药学院生物化学系 Susan Lehman Cullman癌症研究实验室，岁格斯新洋西州立大学Ernest Mario药学院生物化学系，Susan Lehman Cullman癌症研究实验室，岁格斯新洋西州立大学Ernest Mario药学院生物化学系，Susan Lehman Cullman癌症研究实验室，新洋西08854-8020，美国，新洋西08854-8020，美国，新洋西08854-8020，美国 |
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| 摘 要： | 目的研究两个Eph家族分子,EphA5受体及其配体e phrin-A5,在脊髓发育过程中的表达方式。方法β-半乳糖苷酶基因敲入小鼠和配体亲和探针分析受体的表达,两种不同的亲利探针分析配体的表达,基因敲除小鼠作为对照。结果在发育过程中,EphA5表达于脊髓腹侧,而ephrin—A5表达于脊髓背侧。结论EphA5和ephrin-A5在多个脊髓发育阶段都有表达,他们可能在脊髓背腹侧组织结构的建立过程中发挥重要作用。
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| 关 键 词： | 突触引导 胚胎产生 背根神经节 组织化学 碱性磷酸酶亲和探针 β-半乳糖苷酶 |
Expression of the tyrosine kinase receptor EphA5 and its ligand ephrin-A5 during mouse spinal cord development |
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| Christopher R WASHBURN Margaret A.COOPER Renping ZHOU Susan Lehman Cullman Laboratory for Cancer Research. Expression of the tyrosine kinase receptor EphA5 and its ligand ephrin-A5 during mouse spinal cord development[J]. Neuroscience Bulletin, 2007, 0(5) |
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| Authors: | Christopher R WASHBURN Margaret A.COOPER Renping ZHOU Susan Lehman Cullman Laboratory for Cancer Research |
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| Affiliation: | Christopher R WASHBURN Margaret A.COOPER Renping ZHOU Susan Lehman Cullman Laboratory for Cancer Research,Department of Chemical Biology,Ernest Mario School of Pharmacy,Rutgers,The State University of New Jersey,Piscataway NJ 08854-8020,USA |
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| Abstract: | Objectives To study the expression patterns of two Eph family molecules,the receptor EphA5,and the ligand ephrin-A5,during spinal cord development.Methods The receptor expression was analyzed using beta-galactosidase knockin mice,and affinity ligand probe binding.The ligand expression was assessed using two different affinity probes, and knockout mouse tissues as controls.Results,EphA5 was expressed in the ventral spinal cord,while ephrin-A5 was located in the dorsolateral regions of the spinal cord throughout development.Conclusions These results show that EphA5 and ephrin-A5 are expressed over broad developmental stages and may play important roles in establishing the dorsoventral organization of the spinal cord. |
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