125I与5-氟脲嘧啶联合应用治疗复发性甲状腺癌的疗效

目的探讨应用放、化疗粒子联合植入法靶向治疗复发性甲状腺癌的可行性、安全性及短期疗效。方法应用放、化疗粒子联合植入法靶向治疗甲状腺癌术后放疗后复发病人9例。在治疗计划指导下，经B超引导交替植入5．氟脲嘧啶(5-FU)缓释化疗粒子和^125I粒子。结果9例病人手术成功。术后6—9个月CT复查瘤体不同程度缩小，其中1例完全缓解，6例部分缓解，2例无变化，局部控制率为78％。随访8—26个月，现病人全部存活。结论放射性^125I粒子和5-FU缓释化疗粒子联合应用局部植入技术是综合治疗复发性甲状腺癌的较有效手段之一。

Radiochemotherapy with interstitial implantation of 125I seeds and 5-FU slow-release seeds for recurrent thyroid cancer

Objective To investigate the combined treatment technological feasibility,efficacy with interstitial implantation of 125 I seeds and 5-FU slow-release seeds for recurrent thyroid cancer. Methods From March 2002 to December 2003,9 cases of recurrent thyroid cancer were treated with radiochemotherapy. They were all patients with recurrent thyroid cancer after operation and radiation. We implanted alternately 125 I seeds and 5-FU slow-release seeds by guiding of treatment planning system. The MPD of 125 I seed implantation were 60-90 Gy. The mean 8 granules of 125 I seeds and 5-FU 200 mg were used in every patient. Results Fully operating procedure was accomplished for all the patients. No operating complication occurred.No displacement of 125 I seeds was found by cervical X-ray. CT scan showed that the reduced size of tumor changed in different degree. The CR was 11.11%(1/9). The PR was 66.66%(6/9). The NC was 22.22% (2/9). Following up 8-26 months,all patients survived. Conclusion Using radiochemotherapy with interstitial implantation of 125 I seeds and 5-Fu slow-release seeds is safe ,minimally invasive and effective for treatment of recurrent thyroid cancer.