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| 阿仑膦酸钠的一般药理研究 | |
| 引用本文： | 张云,刘国卿,任文华,罗亚东. 阿仑膦酸钠的一般药理研究[J]. 中国现代应用药学, 1998, 15(3): 1-3 |
| 作者姓名： | 张云 刘国卿 任文华 罗亚东 |
| 作者单位： | 1. 南京,210009,中国药科大学药理教研室 2. 南京210097,南京师范大学生物系 3. 重庆,400061,重庆医药工业研究院 |
| 摘 要： | ig阿仑膦酸钠2.5,5和10mg/kg对小鼠的协调运动和自主活动,麻醉猫的呼吸频率、呼吸深度、平均动脉压、心率及心电图无明显影响;iv 5mg/kg对麻醉猫的呼吸、血压、心率及心电图亦无明显影响。iv 10mg/kg对麻醉猫的血压有短暂降低作用,对呼吸、心率及心电图无显著改变。 |
| 关 键 词： | 阿仑膦酸钠 药理学 自主活动 血压 ECG |
| 修稿时间： | 1997-06-10 |
General pharmacological studies of alendronate |
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| Zhang Yun( Zhang Y,Ren Wenhua(Ren WH,Luo Yadong(Luo YD,et al. General pharmacological studies of alendronate[J]. The Chinese Journal of Modern Applied Pharmacy, 1998, 15(3): 1-3 | |
| Authors: | Zhang Yun( Zhang Y Ren Wenhua(Ren WH Luo Yadong(Luo YD et al |
| Affiliation: | Zhang Yun(Zhang Y),Ren Wenhua(Ren WH),Luo Yadong(Luo YD),et al(Department of Pharmacology,China Pharmaceutical university,Nanjing 210009) |
| Abstract: | It was found that alendronate(2.5,5 and 10mg/kg,ig) had no obvious effects on the coordinative motor performance and spontaneous activity in conscious mice, the rate and amplitude of respiration, mean blood pressure, heart rate and ECG in anaesthetized cats.Except for a transient decrease caused by alendronate(10mg/kg,iv) in blood pressure, alendronate(5 or 10mg/kg,iv) also had no significant effects on the respiration, blood pressure, heart rate and ECG in anaesthetized cats. |
| Keywords: | alendronate pharmacology spontaneous activity blood pressure ECG |
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