慢性胃炎患者红细胞免疫功能的改变

目的 :探讨慢性胃炎患者红细胞免疫功能的改变。方法 :对 83例慢性胃炎患者 ,采用免疫粘附酵母菌花环法测其红细胞CR1活性 ,采用免疫粘附促进因子 (RFER)百分率及抑制因子 (RFIR)百分率试验测定其血清中红细胞免疫粘附调节因子。结果 :慢性胃炎组与正常对照组相比 ,红细胞C3 b受体花环 (RBC C3 bRR)率、RFER百分率降低 (P <0 .0 1,P <0 .0 5 ) ,红细胞免疫复合物 (RBC ICR)花环率与RFIR百分率增高 (P <0 .0 5 ,P <0 .0 1) ;治疗后RBC C3 bRR ,RBC ICR ,RFER ,RFIR分别为 (17.2 1± 2 .91) ,(6 .6 2± 1.36 ) ,(81.32± 5 .6 3)和 (2 8.11± 3.11) ,除RFIR外均有明显恢复。慢性胃炎组HP阳性者RBC C3 bRR低于HP阴性患者 ,RBC ICR高于HP阴性患者。结论 :慢性胃炎患者红细胞免疫功能低下 ,HP的感染可能是导致其红细胞免疫功能低下的主要原因之一。

Changes of erythrocyte immune function in the patients with chronic gastritis

Aim: To investigate the immune function of red blood cells (RBC) in the patients with chronic gastritis . Methods: The immune function of RBC in 83 cases with chronic gastritis was dynamically detected with yeast rosette method before and after the treatment. Results: RBC-C 3b receptor rosette (RBC-C 3bRR) rate and RBC immune adherence enhance factor (RFER) rate were lower (P<0.01,P<0.05); and RBC immune complex rosette (RBC-ICR) rate and RBC immune adherence inhibitor factor (RFIR) rate were higher (P<0.05, P<0.01) in patients with chronic gastritis than those in the control group. After treatment, these parameters returned partially except RFIR. The RBC-C 3bRR was lower, and RBC-ICR was higher in the patients with chronic gastritis infected by helicobacter pylori (HP) than those with no Hp. Conclusion: The immune function of RBC is suppressed in the patients with chronic gastritis. Hp might give contribution to the condition.