Red nucleus neurons of Bcl-2 over-expressing mice are protected from cell death induced by axotomy |
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Authors: | Zhou L Connors T Chen D F Murray M Tessler A Kambin P Saavedra R A |
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Affiliation: | Department of Neurobiology and Anatomy, MCP Hahnemann University, Philadelphia, PA 19129, USA. |
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Abstract: | The Bcl-2 proto-oncogene regulates apoptosis and prevents cell death. We studied the effect of Bcl-2 gene over-expression on the survival of axotomized red nucleus (RN) neurons after unilateral hemisection at cervical segment 4/5 (C4/5) in mice. Seventy-five percent of RN neurons survived in Bcl-2 over-expressing mice 1 or 2 months after surgery compared with only 55% of RN neurons in wild-type mice. However, Bcl-2 gene over-expression does not prevent lesion-induced shrinkage of RN neurons. |
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