老年高血压病与血浆Klotho、FGF23蛋白水平的相关性研究

目的：研究血浆Klotho蛋白、成纤维生长因子23（FGF23）与老年高血压病的相关性。方法选择年龄大于60岁高血压病患者180例作为研究组，按血压水平不同分为高血压1级组（60例），高血压2级组（60例），高血压3级组（60例），另选年龄、男女比例大致一致、无高血压病老年人60例作为对照组，应用ELISA检测血浆Klotho、FGF23蛋白水平，应用生化自动分析仪检测血脂水平，并与对照组进行比较，分析其相关性。结果高血压1、2、3级组血浆Klotho低于对照组，FGF23蛋白水平高于对照组，BMI高于对照组（P＜0．05）。随血压水平升高，血浆Klotho蛋白水平逐渐降低，而FGF23蛋白水平逐渐升高。Klotho与FGF23之间有负相关性（r＝－0．282，P＝0．001），Klotho、FGF23与BMI无明显相关性（r＝－0．063，－0．098，P＞0．05）。结论血浆Klotho蛋白、FGF23蛋白水平与血压水平有明显相关性，可能共同参与高血压的发生、发展。

Study on correlation between plasma Klotho,FGF23 protein level and senile hypertension

Objective To explore the correlation between plasma Klotho and FGF23 levels with senile hypertension .Methods Totally 180 cases of hypertension aged more than 60 years old were selected as the research group and divided into the grade 1 hypertension group(60 cases) ,grade 2 hypertension group(60 cases) and grade 3 hypertension group(60 cases) .The age and pro‐portion of male to female were basically consistent .60 elderly people without hypertension were selected as the control group .The level of plasma Klotho and FGF23 protein were tested by ELISA .The lipid level was detected by the automatic biochemical analy‐zer .The detection results were compared with those in the control group for analyzing their correlation .Results Plasma Klotho protein level in each hypertension group was lower than that in the control group ,while plasma FGF23 protein level and BMI were significantly higher than those in the control group(P<0 .05) .With the blood pressure level increase ,plasma Klotho protein level was gradually decreased ,while FGF23 protein level was gradually increased .The negative correlation was found between plasma Klotho protein and FGF23 protein (r= -0 .282 ,P=0 .001) .Plasma Klotho protein and FGF23 protein had no obvious correlation with BMI (r= -0 .063 ,-0 .098 ,P>0 .05) .Conclusion Plasma Klotho protein and FGF23 protein levels have obvious correlation with the blood pressure level ,which may jointly participate in the occurrence and development of hypertension .