明胶酶与角膜新生血管

目的：着重阐述明胶酶的生理特性和调节以及它在角膜新生血管生成中的作用。资料来源：应用计算机检索PUBMED1990-01/2006-01的相关文章,检索词为“gelatinase,cornea,neovascularization”并限定文章语言种类为English。同时计算机检索CNKI2000-01/2006-01的相关文章,检索词为“明胶酶,角膜,新生血管”,并限定文章语言种类为中文。资料选择：对资料进行初审,并察看每篇文献后的引文。纳入标准：①具有原创性,论点论据可靠的实验文章。②观点明确,分析全面的综述文章。排除标准：重复研究。资料提炼：共收集到30篇符合纳入标准的文献,涉及明胶酶的生理特性、调节,在角膜新生血管中的作用等方面。资料综合：①角膜新生血管形成包括毛细血管内皮下基底膜降解、内皮细胞迁移和增殖、新的血管形成和新的基底膜形成等一系列过程,角膜细胞外基质是参与这个过程的主要成分。②明胶酶是一类参与角膜细胞外基质的分化、黏附、迁移、损伤修复及组织重塑的蛋白水解酶,受基因、酶原、活化后3个水平的调节。③对实验性角膜新生血管发生中明胶酶表达的研究表明,明胶酶是新生血管发生中的重要因子,用明胶酶抑制剂可以抑制新生血管的发生。结论：明胶酶在角膜新生血管发生发展中,发挥着不可替代的作用,通过抑制其活性来阻止角膜新生血管发生,可能成为治疗新生血管相关性角膜疾病的新策略。

Gelatinase and corneal neovascularization

OBJECTIVE： To explain the biological features and accommodations of gelatinase and its role in corneal angiogenesis. DATA SOURCES： Pubmed was searched with computer for related articles between January 1990 and January 2006 with the key words of ＂gelatinase, cornea, neovasculadzation＂ in English. Meanwhile, CNKI was searched for relevant articles between January 2000 and January 2006 with the same key words in Chinese.
STUDY SELECTION： The data ware selected firstly, and the references of each article were looked up. Inclusive criteria： （1） Origin and reliable experimental articles;（2）Well analyzed review articles with clear opinions. Exclusion criteria： Repetitive studies.
DATA EXTRACTION： A total of 30 literatures met the inclusive criteria ware collected, involving in the biological features and accommodations of gelatinase and its role in comeal neovascularization.
DATA SYNTHESIS： （1） Comeal neovascularization includes the degradation of the basement membrane, endothelial call migration and proliferation, new vessel and basement membrane formation. The extracallular matrix of the comea is the essential component of the process. （2） Gelatineses participates the differentiation, adhering, immigration, damage reparation and tissue remodeling of the ECM, which was regulated by 3 horizontal accommodations of gene, zymogen and post-activation. （3） The investigation of the experiments of CNV indicates that gelatinase is an important factor of CNV. The inhibitor of gelatinase can repress the occurrence of the new vessels.
CONCLUSION： Gelatinase plays an irreplaceable role in the occurrence and development of comeal neovascularizaUon. Restraining its activity to confront corneal angiogenesis is probably a new method for neovascularization related corneal diseases.