| 肾母细胞瘤中CyclinD1蛋白的表达及其意义 |
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| 引用本文： | 吴红芳,符宝敏,陈肖鸣,王宗敏. 肾母细胞瘤中CyclinD1蛋白的表达及其意义[J]. 临床儿科杂志, 2010, 28(1) |
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| 作者姓名： | 吴红芳 符宝敏 陈肖鸣 王宗敏 |
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| 作者单位： | 温州医学院育英儿童医院,浙江温州,325027;南阳医学高等专科学校病理教研室,河南南阳,473000 |
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| 摘 要： | 目的探讨CyclinD1蛋白在肾母细胞瘤中表达及其意义。方法将28例肾母细胞瘤和19例瘤旁肾组织制作组织芯片,并用免疫组织化学方法检测其中CyclinD1蛋白及p53蛋白的表达。结果CyclinD1和p53蛋白在肾母细胞瘤和瘤旁肾组织标本中的阳性表达率差异有统计学意义(P<0.05),在肾母细胞瘤不同分化程度组差异亦有统计学意义(P<0.05)。CyclinD1蛋白表达与p53蛋白表达呈正相关(P<0.05)。结论CyclinD1及p53可作为判断肾母细胞瘤分化程度的标志物,CyclinD1蛋白异常表达及p53突变可能在肾母细胞瘤发生中发挥重要作用。
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| 关 键 词： | CyclinD1蛋白 p53蛋白 肾母细胞瘤 免疫组化 |
Expression of CyclinD1 protein in nephroblastoma |
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| WU Hong-fang,FU Bao-min,CHEN Xiao-ming,WANG Zhong-min. Expression of CyclinD1 protein in nephroblastoma[J]. The Journal of Clinical Pediatrics, 2010, 28(1) |
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| Authors: | WU Hong-fang FU Bao-min CHEN Xiao-ming WANG Zhong-min |
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| Affiliation: | 1.Yuying Children Hospital/a>;Wenzhou Medical College/a>;Wenzhou 325027/a>;Zhejiang/a>;China/a>;2.Department of Pathology/a>;Nanyang Medical College/a>;Nanyang 473000/a>;Henan/a>;China |
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| Abstract: | Objective To investigate the expression of CyclinD1 protein in nephroblastoma. Methods The tissue microarray were made in 28 cases of nephroblastoma and 19 cases of renal tissue adjacent to tumor. The expression of CyclinD1 and p53 proteins were detected by immunohistochemistry. Results The positive rate of the expression of CyclinD1 and p53 protein was significantly different between nephroblastoma and renal tissue adjacent to tumor (P < 0.05). The positive rate of the expression of CyclinD1 and p53 protei... |
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| Keywords: | CyclinD1 p53 nephroblastoma immunohistochemistry |
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