| 血清层粘连蛋白ELISA检测及其在肝病中的临床意义 |
| |
| 引用本文： | 高锋 孔宪涛 刘焱 谢映华. 血清层粘连蛋白ELISA检测及其在肝病中的临床意义[J]. 解放军医学杂志, 1994, 19(2): 83-85 |
| |
| 作者姓名： | 高锋 孔宪涛 刘焱 谢映华 |
| |
| 作者单位： | 第二军医大学长征医院,200003 |
| |
| 基金项目： | 上海市科学技术发展基金项目 |
| |
| 摘 要： | 应用双抗体夹心ELISA方法．分析138倒肝病患者血清层粘连蛋白（1aminirt．LN）吉量，发现LN随肝损害的加重而升高．慢迁肝（151．2±69．3μg／L）、慢活肝（207．3±78．6μg／L）、肝癌（206．6±104.3μ／L）及肝肝变（296．0±112．4μg／L）血清LN均明显高于正常对照组（100．3±42．4μg／L）（P〈0．01）．以慢活肝时LN值加一个标准差为界，LN诊断肝硬变的敏感性为87％I特异性为90％．诊断符合率为88%．揭示LN是判断慢性肝脏损害程度和诊断肝纤维化的一个良好指标。
|
| 关 键 词： | 血清层粘连蛋白 ELISA检测 肝病 ELISA方法 肝脏疾病 |
ASSAY OF SERUM HUMAN LAMININ USING ELISA METHOD: ITS CLINICAL SIG- NIFICANCE IN LIVER DISEASES |
| |
| Gao Feng,Kong Xiantao,Liu Yan,et al.. ASSAY OF SERUM HUMAN LAMININ USING ELISA METHOD: ITS CLINICAL SIG- NIFICANCE IN LIVER DISEASES[J]. Medical Journal of Chinese People's Liberation Army, 1994, 19(2): 83-85 |
| |
| Authors: | Gao Feng Kong Xiantao Liu Yan et al. |
| |
| Affiliation: | Gao Feng,Kong Xiantao,Liu Yan,et al. Chang Zheng Hospital,Shanghai 200003 |
| |
| Abstract: | An ELISA for human serum laminin was set up. Serum laminin levels were determined in 138 patients with liver diseases. The level of laminin was significantly increased in patients with chronic persistent hepatitis, chronic active hepatitis, hepatocellular carcinoma and liver cirrhosis, as compared with healthy controls and patients with non-liver disases. The diagnostic specificity, sensitivity, a,d diagnostic accuracy for liver cirrbosis were 0.90, 0. 37, 0. 88, respectively. The results suggested that assay of laminin in serum may he useful to assess the degree of chronic liver damage and may be helpful to the diagnosis of liver cirrhosis. |
| |
| Keywords: | Lamimin ELISA Liver disease |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
