| 海南粗榧新碱衍生物HH07A经大鼠肝微粒体的代谢转化研究 |
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| 引用本文： | 张文江,周同惠,崔燕岩.海南粗榧新碱衍生物HH07A经大鼠肝微粒体的代谢转化研究[J].药学学报,1997,32(2):116-120. |
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| 作者姓名： | 张文江 周同惠 崔燕岩 |
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| 作者单位： | 中国医学科学院、中国协和医科大学药物研究所 |
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| 摘 要： | 用大鼠肝微粒体体外代谢法对HH07A进行了代谢转化研究。用HPLC结合二极管阵列检测器对体外代谢体系进行了分析,判断在体外代谢体系中HH07A有二个代谢产物,并用减压柱色谱、薄层色谱及高效液相色谱法分离制备了其中一个代谢物的纯品,经核磁共振、质谱、红外、紫外光谱确定了结构。
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| 关 键 词： | 海南粗榧新碱衍生物HH07A 体外代谢 高效液相色谱法 |
| 收稿时间： | 1996-04-23 |
THE IN VITRO METABOLISM OF HAINANENSINE DERIVATIVE HH07A BYT LIVER MICROSOMES |
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| WJ Zhang,TH Zhou and YY Cui.THE IN VITRO METABOLISM OF HAINANENSINE DERIVATIVE HH07A BYT LIVER MICROSOMES[J].Acta Pharmaceutica Sinica,1997,32(2):116-120. |
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| Authors: | WJ Zhang TH Zhou and YY Cui |
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| Institution: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050. |
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| Abstract: | The metabolism of hainanensine derivative HH07A has been studied in vitro with rat microsomes. A method of HPLC DAD was developed for screening the metabolites from the microsomal incubation system. Two metabolites were found according to their UV spectra. One of them was extracted and purified with preparative HPLC and TLC, its chemical structure was identified by UV, IR, MS and NMR. |
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| Keywords: | Hainanensine derivative HH07A Metabolism in vitro HPLC |
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