Interleukin 8 and venous thrombosis: evidence for a role of inflammation in thrombosis |
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Authors: | van Aken Benien E Reitsma Pieter H Rosendaal Frits R |
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Affiliation: | Laboratory for Experimental Internal Medicine and Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. |
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Abstract: | Elevated plasma levels of interleukin 8 (IL-8) were previously shown to be associated with recurrent venous thrombosis. To assess the risk of venous thrombosis, IL-8 plasma concentrations were measured in patients and control subjects of the Leiden Thrombophilia Study (LETS). This population based case-control study included 474 patients with a first deep-vein thrombosis and 474 age- and sex-matched controls. The risk of venous thrombosis for subjects with elevated IL-8 levels (above 90th percentile of controls) compared with subjects with IL-8 levels below the 90th percentile was increased 1.8-fold (95%CI 1.2-2.8). Adjusted for age and sex, the odds ratio was 1.9 (95%CI 1.3-2.8). IL-8 concentrations were weakly correlated with age, male sex, and concentrations of C-reactive protein, factor VIII coagulation activity and homocysteine, but adjustment for these factors did not substantially affect the association between IL-8 and venous thrombosis. Our results suggest that IL-8 is a risk factor for venous thrombosis. |
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Keywords: | venous thrombosis epidemiology interleukin 8 inflammation risk factors |
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