| 烟碱对M受体激动剂抑制自发活动的调节 |
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| 引用本文： | 汪 海 崔文玉 刘传缋. 烟碱对M受体激动剂抑制自发活动的调节[J]. 中国药理学与毒理学杂志, 1996, 10(2): 98-100 |
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| 作者姓名： | 汪 海 崔文玉 刘传缋 |
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| 作者单位： | 军事医学科学院毒物药物研究所 |
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| 摘 要： | 间隔１０ｍｉｎ两次ｉｐ烟碱０．０２和０．２０ｍｇ·ｋｇ－１，小鼠对烟碱抑制自发活动的作用产生急性耐受，使Ｍ受体激动剂氧化震颤素５０μｇ·ｋｇ－１抑制自发活动的作用显著增强．间隔５ｍｉｎ两次ｉｐ烟碱０．２５和０．５０ｍｇ·ｋｇ－１，大鼠对烟碱抑制自发活动的作用产生急性耐受，使Ｍ受体激动剂槟榔碱５ｍｇ·ｋｇ－１抑制自发活动的作用也显著增强．提示反复注射烟碱诱导动物对烟碱急性耐受后，Ｍ受体激动剂抑制自发活动的作用显著增强．
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| 关 键 词： | 烟碱；药物耐受性；活动，自发受体，胆碱能；药物相互关系 |
| 收稿时间： | 1995-07-10 |
Modulation of nicotine on muscarinic agonist-depressed spontaneous locomotor activity |
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| WANG Hai, CUI Wen-Yu, LIU Chuan-Gui. Modulation of nicotine on muscarinic agonist-depressed spontaneous locomotor activity[J]. Chinese Journal of Pharmacology and Toxicology, 1996, 10(2): 98-100 |
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| Authors: | WANG Hai CUI Wen-Yu LIU Chuan-Gui |
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| Affiliation: | (Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850) |
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| Abstract: | After acute nicotine tolerance developed by repeating 0.02 and 0.20 mg·kg-1 doses at 10 min intervals in mice, the inhibitory effect of muscarinic agonist oxotremorine at 50 μg·kg-1 on spontaneous locomotor activity was potentiated. After acute nicotine tolerance developed by repeating 0.25 and 0.50 mg·kg-1 doses at 5 min intervals in rats, the inhibitory effect of muscarinic agonist arecoline at 5 mg·kg-1 on spontaneous locomotor activity was also potentiated. The results indicate that the inhibitory effects of muscarinic agonists on spontaneous locomotor activity are potentiated in acute nicotine tolerant rats and mice. |
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