| 川芎嗪对麻醉牛蛙肺微循环的影响 |
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| 引用本文： | 魏敏杰 小山富康赵乃才 李 智. 川芎嗪对麻醉牛蛙肺微循环的影响[J]. 中国药理学与毒理学杂志, 1996, 3(3): 193-195 |
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| 作者姓名： | 魏敏杰 小山富康赵乃才 李 智 |
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| 作者单位： | 中国医科大学药理学教研室，北海道大学医学部生理学教室 |
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| 摘 要： | 用实体显微装置录像系统，观察了川芎嗪对麻醉蛙肺微循环的影响，结果表明：川芎嗪具有舒张肺微动脉，降低其阻力，促进肺微循环血流的作用．且有较好的剂量依赖关系．０．０１～１０ｍｍｏｌ·Ｌ－１川芎嗪ｉｖ７ｍｉｎ时，加快肺动脉血流的作用最强，ｉｖ后１０ｍｉｎ时，舒张肺微动脉作用最强．提示川芎嗪出现加快肺动脉血流作用先于出现舒张肺微动脉作用
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| 关 键 词： | 川芎嗪；微循环，肺；血流速度；小动脉 |
| 收稿时间： | 1995-08-02 |
Influence of tetramethylpyrazine on pulmonary microcirculation in anesthetized bullfrogs |
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| WEI Min-Jie, KOYAMA Tomiyashu, ZHAO Nai-Cai, LI Zhi. Influence of tetramethylpyrazine on pulmonary microcirculation in anesthetized bullfrogs[J]. Chinese Journal of Pharmacology and Toxicology, 1996, 3(3): 193-195 |
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| Authors: | WEI Min-Jie KOYAMA Tomiyashu ZHAO Nai-Cai LI Zhi |
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| Affiliation: | (Department of Pharmacology, China Medical University, Shenyang 110001; 1. Department of Physiology, Hokkaidou University, Sapporo 060, Japan) |
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| Abstract: | The effects of tetramethylpyrazine (TMP) on pulmonary microcirculation were studied in exposed lung of bullfrogs by observing directly the blood flow in the pulmonary capillary network. The results indicate that TMP causes vasodilation in pulmonary microcirculation in vivo, and the effects are directly proportional to the dosages of the drug. When TMP (0.01-10.0 mmol·L-1) was injected intravenously into the bullforg, the blood flow velocity reached a maximum in 7 min, and arteriole diameter reached a maximum in 10 min. |
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| Keywords: | tetramethylpyrazine microcirculation pulmonary blood flow velocity arterioles |
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