| 山莨菪碱对烫伤大鼠心肌的保护作用 |
| |
| 引用本文： | 秦卫军 姚秀娟 孙向东 陈水英 梅其柄 赵德化. 山莨菪碱对烫伤大鼠心肌的保护作用[J]. 中国药理学与毒理学杂志, 1996, 10(1): 73-74 |
| |
| 作者姓名： | 秦卫军 姚秀娟 孙向东 陈水英 梅其柄 赵德化 |
| |
| 作者单位： | 第四军医大学药理教研室 |
| |
| 摘 要： | 山莨菪碱对烫伤大鼠心肌的保护作用秦卫军姚秀娟孙向东陈水英梅其柄赵德化（第四军医大学药理教研室，西安７１００３２）近年来文献报道严重烫伤后心血管功能及结构方面有很大改变，这往往是加重烧伤休克而导致多脏器衰竭的重要原因之一［１］．故烫伤早期补液的同时保护...
|
| 关 键 词： | 山莨菪碱；烫伤；过氧化脂质类；磷脂酶A_2类 |
| 收稿时间： | 1995-01-03 |
Protective effect of anisodamine on myocardium in postburn rat |
| |
| QIN Wei-Jun, YAO Xiu-Juan, SUN Xiang-Dong, CHEN Shui-Ying, MEI Qi-Bing, ZHAO De-Hua. Protective effect of anisodamine on myocardium in postburn rat[J]. Chinese Journal of Pharmacology and Toxicology, 1996, 10(1): 73-74 |
| |
| Authors: | QIN Wei-Jun YAO Xiu-Juan SUN Xiang-Dong CHEN Shui-Ying MEI Qi-Bing ZHAO De-Hua |
| |
| Affiliation: | (Department of Pharmacology, The Fourth Military Medice University, Xi’an 710032) |
| |
| Abstract: | Effect of anisodamine (Ani) on myocardial injury after burn was observed in rats inflicted with burn of Ⅲ degree on 30% total body surface area (TBSA). Ani 1, 5 and 10 mg·kg-1 was given every 4 h ip after burn injury. lt was found that Ani significantly decreased the release of creatine phospokinase, lactate dehydrogenase and malondialdehyde content, inhibited phospholipase A2 (PLA2) activity and also increased superoxide dismutase activity 12 h after burn. The results suggested that the protective mechanism of Ani on myocardium after burn injury might be related to membrane stabilization through antilipid peroxidation and PLA2 activity inhibition. |
| |
| Keywords: | anisodamine burn lipid pero- xides phospholipase A 2 |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《中国药理学与毒理学杂志》浏览原始摘要信息 |
|
点击此处可从《中国药理学与毒理学杂志》下载全文 |
