梭曼对大鼠周围消化功能的影响

梭曼对大鼠周围消化功能的影响于桂华王玉琛何湘平刘传缋（军事医学科学院毒物药物研究所，北京１００８５０）动物实验中发现，肌注梭曼可明显抑制大鼠摄食活动，且持续时间较长［１］．为探讨梭曼抑制摄食与其对周围胃肠道作用的关系，本实验从运动，分泌和吸收三个方面...

Effect of soman on peripheral digestive function in rat

In order to study effect of soman on peripheral digestive function in rat, the methods for recording myoelectric activity of small intestine and for determining quantity of gastric acid and rate of intestinal absorption on D-glucose and L-tryptophane were used. The experimental results demonstrated that the amplitude of small intestinal myoelectric spiking waves was increased by 36%-50%, the quiescent phase of migrating myoelectric complex (MMC) was shortened by 57%-70%, and the irregular spiking phase of MMC was prolonged by 72%-124% after soman 35 μg·kg^-1 im. These effects could be partially prevented by HI-6 10 mg·kg^-1 im. The quantity of gastric acid was reduced by 38% after soman 35 μg·kg^-1 im. The above mentioned effects of soman lasted about 24-48 h. Soman had no effects on function of absorbing D-glucose and L-tryptophane of small intestine and activity of pepsin.