| 赛庚啶对大鼠脑缺血再灌注损伤的保护作用 |
| |
| 引用本文： | 粱 健王美纳 杨庆余王 菁. 赛庚啶对大鼠脑缺血再灌注损伤的保护作用[J]. 中国药理学与毒理学杂志, 1996, 3(3): 235-236 |
| |
| 作者姓名： | 粱 健王美纳 杨庆余王 菁 |
| |
| 作者单位： | 西安医科大学基础医学院药理学教研室 |
| |
| 摘 要： | 赛庚啶对大鼠脑缺血再灌注损伤的保护作用粱健１王美纳杨庆余２王菁３（西安医科大学基础医学院药理学教研室，西安７１００６１）赛庚啶（ｃｙｐｒｏｈｅｐｔａｄｉｎｅ，Ｃｙｐ）为一哌啶类化合物，具有抗组胺和抗５－羟色胺作用．近年来相继发现其有抗心律失常，抗休克...
|
| 关 键 词： | 赛庚啶 脑缺血 再灌注损伤 脑梗塞 超氧化物歧化酶 丙二醛 |
| 收稿时间： | 1995-09-15 |
Protective effects of cyproheptadine on cerebral ischemia-reperfusion injury in rats |
| |
| LIANG Jian, WANG Mei-Na, YANG Qing-Yu, WANG Jing. Protective effects of cyproheptadine on cerebral ischemia-reperfusion injury in rats[J]. Chinese Journal of Pharmacology and Toxicology, 1996, 3(3): 235-236 |
| |
| Authors: | LIANG Jian WANG Mei-Na YANG Qing-Yu WANG Jing |
| |
| Affiliation: | (Department of Pharmacology, School of Basic Medical Sciences, Xi’an Medical University, Xi’an 710061) |
| |
| Abstract: | Acute cerebral ischemia-reperfusion injury was produced by reversible middle artery occlusion without craniectomy in rats. Cyproheptadine (Cyp) 1.5 and 2 mg·kg-1 iv decreased the size of cerebral infarction after ischemia for 2 h followed by reperfusion for 3 h. Cyp (2 mg·kg-1 iv) improved brain electrical activity, increased the activity of superoxide dismutase, and decreased the content of malondialdehyde in brain. These results indicate that Cyp has protective effects against cerebral ischemia-reperfusion injury, probably through inhibiting free radical and subsequent lipid peroxidation. |
| |
| Keywords: | cyproheptadine cerebral ischemia reperfusion injury cerebral infarction superoxide dismutase malondialdehyde |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《中国药理学与毒理学杂志》浏览原始摘要信息 |
|
点击此处可从《中国药理学与毒理学杂志》下载全文 |
