| 替罗非班对发病6~12h急性ST段抬高型心肌梗死患者急诊PCI中无再流的作用 |
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| 作者单位： | 浦东新区公利医院心内科，上海交通大学医学院附属瑞金医院心脏科，上海交通大学医学院附属瑞金医院心脏科 |
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| 摘 要： | 目的:探讨血小板Ⅱb/Ⅲa受体拮抗剂替罗非班对发病6~12h的急性ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗(PCI)后无再流的影响。方法:将症状发生至急诊PCI6~12h的STEMI患者随机分为替罗非班组(50例)和对照组(50例)。记录两组基础临床情况、PCI后无再流、心力衰竭、住院期间及术后180d主要心脏不良事件(MACE),包括死亡再梗死再次靶血管重建的发生率。结果:两组梗死相关动脉(IRA)PCI后TIMI3级血流发生无显著差异。与对照组相比,替罗非班组PCI前IRA TIMI 3级血流、术后梗死区心肌灌注分级(TMP)3级明显增加,无再流发生率降低(P<0.05)。心力衰竭减少27.4%,住院期间MACE发生率相似,但于术后180d降低10.85%(P<0.05)。结论:急诊PCI联合替罗非班治疗发病6~12h的STEMI患者,可进一步减少无再流发生,提高心肌灌注,并改善临床预后。
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| 关 键 词： | 急性ST段抬高型心肌梗死 替罗非班 无再流 经皮冠状动脉介入治疗 |
Effects of tirofiban on no-reflow in patients with acute ST-elevation myocardial infarction admitted between 6 and 12 hours of symptom onset undergoing primary percutaneous coronary intervention |
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| WANG Hairong,QIU Jianping,LU Jide,GONG Peihua,DOU Guizhen,SHEN Weifeng,ZHANG Qi..Dept.of Cardiology,Gongli Hospital of Pudong District,Shanghai ,.Dept.of Cardiology,Ruijin Hospital,Medical College of Shanghai Jiaotong University,Shanghai ,China. Effects of tirofiban on no-reflow in patients with acute ST-elevation myocardial infarction admitted between 6 and 12 hours of symptom onset undergoing primary percutaneous coronary intervention[J]. , 2008, 0(4) |
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| Authors: | WANG Hairong QIU Jianping LU Jide GONG Peihua DOU Guizhen SHEN Weifeng ZHANG Qi..Dept.of Cardiology Gongli Hospital of Pudong District Shanghai .Dept.of Cardiology Ruijin Hospital Medical College of Shanghai Jiaotong University Shanghai China |
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| Affiliation: | WANG Hairong1,QIU Jianping1,LU Jide1,GONG Peihua1,DOU Guizhen1,SHEN Weifeng2,ZHANG Qi2.1.Dept.of Cardiology,Gongli Hospital of Pudong District,Shanghai 200135,2.Dept.of Cardiology,Ruijin Hospital,Medical College of Shanghai Jiaotong University,Shanghai 200025,China |
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| Abstract: | |
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| Keywords: | Acute ST-segment elevation myocardial infarction Tirofiban No-reflow Percutaneous coronary intervention |
| 本文献已被 CNKI 等数据库收录！ |
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