2型糖尿病患者血清护骨素水平与大血管并发症的关系

目的探讨2型糖尿病患者血清护骨素水平与大血管并发症的关系。方法88例2型糖尿病患者根据有无大血管并发症分为2型糖尿病并发大血管病变组(46例)及无大血管病变组(42例),同时选择年龄、性别相匹配的40例健康者为对照组。采用酶联免疫吸附法测定各组血清护骨素水平,并进行组间比较。结果2型糖尿病并大血管病变组血清护骨素水平(4.12±0.64 ng/L)显著高于无大血管病变组(2.78±0.59 ng/L)与对照组(2.29±0.37 ng/L,P<0.01),无大血管病变组与对照组比较差异无显著性(P>0.05)。相关及回归分析表明2型糖尿病血清护骨素水平与空腹血糖、餐后2 h血糖、糖化血红蛋白、胰岛素抵抗指数及高敏C反应蛋白呈明显正相关(P<0.05)。结论血清护骨素水平与糖尿病大血管并发症相关联,护骨素可能在2型糖尿病慢性血管并发症的发生中起一定作用。

Relationship Between Serum Osteoprotegerin and Macrovascular Complications in Type 2 Diabetes

Aim To study the relationship between the serum osteoprotegerin(OPG) levels and macrovascular complications in type 2 diabetes. Methods 88 type 2 diabetes were divided into macrovascular complications group and no macrovascular complications group.The clinical and biochemical data of all subjects were recorded and fasting serum OPG levels were measured with enzyme-linked immunosorbent assay(ELISA). Results The serum OPG level in type 2 diabetes with macrovascular complications was 4.12±0.64 ng/L,which was significantly higher than that of no macrovascular complications group(2.78±0.59 ng/L) and control group(2.29±0.37 ng/L,P<0.01).The serum OPG level in type 2 diabetes was positively correlated with fasting plasma glucose(FPG),2 h plasma glucose(2hPG),glycosylated hemoglobin A1c(HbA1c),homeostasis model assessment of insulin resistance(HOMA-IR) and high sensitive C reactive protein(hs-CRP)(P<0.05).The Logistic regression analysis showed the macrovascular complications in type 2 diabetes had significant correlation with serum OPG,FPG and hs-CRP. Conclusions The correlation between higher serum OPG level and macrovascular complications in type 2 diabetes suggests OPG may play an important role in the pathogenesis of macrovascular complications.