| CCK对孤束核中胃扩张相关神经元电活动的影响 |
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| 引用本文： | 王芳,陆杰,陈卫,隋红. CCK对孤束核中胃扩张相关神经元电活动的影响[J]. 重庆医科大学学报, 2006, 31(5): 684-687 |
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| 作者姓名： | 王芳 陆杰 陈卫 隋红 |
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| 作者单位： | 山东省济南市出入境检验检疫局;山东省济南市出入境检验检疫局;山东省济南市出入境检验检疫局;山东省济南市出入境检验检疫局 |
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| 基金项目： | 本研究获得原美国纽约州Rochester大学医学中心消化和肝病中心William Y.Chey教授及李平教授在药品和技术上的大力支持,在此致以衷心感谢! |
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| 摘 要： | 目的：研究胆囊收缩素对孤束核中胃扩张相关神经元电活动的影响。方法：记录乌拉坦麻醉大鼠孤束核内胃扩张相关神经元的电活动，观察胃扩张以及静脉注射CCK对神经元电活动的影响。结果：外周静脉注射CCK对孤束核内胃扩张相关神经元自发电活动的影响是多样的，既具有兴奋效应（9／14），也具有抑制效应（5／14）。但对于胃扩张诱发的孤束核神经元放电，不管是胃扩张兴奋性神经元还是胃扩张抑制性神经元，CCK均表现为抑制效应。结论：外周CCK可以影响孤束核内胃扩张相关神经元的活动。
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| 关 键 词： | 胆囊收缩素 孤束核 胃扩张 |
| 文章编号： | 0253-3626(2006)05-0684-04 |
| 收稿时间： | 2005-12-31 |
| 修稿时间： | 2005-12-31 |
Effect of Cholecystokinin on Electricity Activity of Gastric Distention Related Neurons in NTS |
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| WA NG Fang, et al. Effect of Cholecystokinin on Electricity Activity of Gastric Distention Related Neurons in NTS[J]. Journal of Chongqing Medical University, 2006, 31(5): 684-687 |
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| Authors: | WA NG Fang et al |
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| Affiliation: | Department of Physiology, College of Basic Medicine, Chongqing Medical University |
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| Abstract: | Objective:To explore the effect of cholecystokinin on electricity activity of gastric distention related neurons in the nucleus of tractus solitarius.Methods: The effects of gastric distention and intravenous CCK on electricity activity of gastric distention related neurons in the nucleus of tractus solitarius were investigated in urethane anesthetized rats.Results:Intravenous CCK could obviously influence the spontaneous activity of gastric distention related neurons in the nucleus of tractus solitarius.Intravenous CCK could increase the discharge of gastric distention(GD)excited neurons(9/14)and decrease the discharge of GD inhibited neurons(5/14) in NTS.Howerer,the effect of CCK on gastric distention-induced discharge of GD related neurons was always inhibitory.Conclusion:Circulating CCK and gastric distention have both excitatory and inhibitory effects on the electricity activity of gastric distention related neurons in NTS,but the effect of CCK on gastric distention-induced discharge of GD related neurons is inhibitory.The effect of gastric distention on spantenous discharge of neurons in NTS is similar to circulating CCK. |
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| Keywords: | Cholecystokinin The Nucleus of Solitary Tract Gastric Distention |
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