| 内质网应激反应的分子机制 |
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| 引用本文： | 徐文静,张君,陆环,谢建新.内质网应激反应的分子机制[J].国际内分泌代谢杂志,2009,29(1):47-50. |
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| 作者姓名： | 徐文静 张君 陆环 谢建新 |
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| 作者单位： | 石河子大学医学院省部共建新疆地方病与民族高发病教育部重点实验室,832000; |
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| 基金项目： | 新疆生产建设兵团医药卫生专项基金 |
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| 摘 要： | 已知缺氧、营养物质缺乏、氧化应激、异常糖基化反应、钙代谢紊乱等都能引起内质网应激反应,并表现为3个步骤:蛋白质合成暂停、内质网应激蛋白表达和细胞凋亡等,每一过程的分子机制现已逐步被揭示.当细胞内质网稳态遭到破坏时,细胞小能正确合成蛋白质,也不能发挥正常的生理功能,甚至会出现细胞凋亡.掌握内质网应激过程对进一步理解糖尿病、心脑组织缺血性梗死、神经退行性病变等多种疾病的发生机制有十分重要的理论意义.
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| 关 键 词： | 内质网应激 未折叠蛋白反应 内质网相关性死亡 |
Molecular mechanisms of endoplasmic reticultum stress |
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| XU Wen-jing,ZHANG Jun,LU Huan,XIE Jian-xin.Molecular mechanisms of endoplasmic reticultum stress[J].International JOurnal of Endocrinology and Metabolism,2009,29(1):47-50. |
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| Authors: | XU Wen-jing ZHANG Jun LU Huan XIE Jian-xin |
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| Abstract: | Homocysteine,oxidative stress,nutrient stress and calcium metabolism disturbance were proved to induce endoplasmic reticulum stress cascade processes, including inhibition of protein synthesis ini-tiation, expression of endoplasmic retieulum stress protein, and/or endoplasmic reticulum related apoptosis. When endocytoplasmic reticulum homeostasis is destroied, protein can not be correctly synthetized and can not perform normal physiological function, then cause apoptosis. A comprehensive understanding of the impact of the ER stress pathway within those suffering cells on their pathological process might be conducive to pro-vide a new target for the prevention and treatment of those diseases. |
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| Keywords: | Endoplasmic reticulum stressUnfolded protein responseEndoplasrnic reticulum asso-ciated death |
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