鼻咽癌患者血清血管生长素水平的临床意义初探

目的:分析血管形成素(ANG)在鼻咽癌(NPC)患者血循环中的含量及其临床意义。方法:采用酶联免疫吸附试验(ELISA)测定42例NPC患者(NPC组)和30例健康者(对照组)血清ANG水平。结果:NPC组治疗前血清ANG水平为(371.4±123.5)μg/L,显著高于对照组的(292.5±74.2)μg/L(P<0.01),且血清ANG水平随着NPC临床分期的增加而升高(P<0.05);治疗后血清ANG水平为(340.6±112.4)μg/L,比治疗前明显降低(P<0.05),但仍高于对照组(P<0.05)。结论:NPC患者血清ANG水平升高,且其升高的程度与肿瘤的进展有关。

Serum angiogenin concentration in nasopharyngeal carcinoma patients and its clinical significance

OBJECTIVE: To determine the serum angiogenin (ANG) concentration in patients with nasopharyngeal carcinoma (NPC) and analyze its clinical significance. METHOD: Forty-two NPC patients and 30 healthy controls entered this study. Serum ANG level was quantitatively analyzed by enzyme-linked immunosorbent assay (ELISA). RESULT: The mean level of serum ANG in untreated NPC was (371.4 +/- 123.5) microg/L, which was significantly higher than that in healthy controls(292.5 +/- 74.2) microg/L (P < 0.01). Furthermore, the serum level of ANG increased with the development of tumor (P < 0.05). After treatment, all patients reached a response: partial response (PR) or complete response (PR), and the serum ANG level was (340.6 +/- 112.4) microg/L, which was significantly lower than that in untreated ones (P < 0.05), but still higher than that in healthy controls (P < 0.05). CONCLUSION: Our results indicate that the serum ANG level increases in patients with NPC, and is correlate with primary tumor progression.