| 糖皮质激素局部封闭对兔肌肉组织的影响 |
| |
| 引用本文： | 苏连澍,张政,王广舜,徐向英,赵宝泉. 糖皮质激素局部封闭对兔肌肉组织的影响[J]. 中国中西医结合外科杂志, 2011, 17(4): 365-368. DOI: 10.3969/j.issn.1007-6948.2011.04.010 |
| |
| 作者姓名： | 苏连澍 张政 王广舜 徐向英 赵宝泉 |
| |
| 作者单位： | 天津医科大学宝坻临床学院骨科,宝坻,301800 |
| |
| 摘 要： | 目的：探讨糖皮质激素局部封闭疗法肌肉组织萎缩的形态学基础。方法：选择健康成年新西兰大耳白兔24只,随机分为实验组与对照组。实验组肌注糖皮质激素,对照组注射相应剂量的生理盐水。取相应部分肌组织,光镜及电镜下观察肌肉组织显微及超微结构及图像分析。结果：实验组肌肉纤维排列紊乱,肌细胞完整,未见变性坏死,细胞核位于肌细胞的边缘,肌节部分消失,肌细胞直径减小,单位面积下肌细胞数目明显增多,与对照组细胞最大直径和细胞数差异有统计学意义。电镜下臀大肌纤维实验组肌注侧与对照侧明显减小,II型肌纤维电子密度明显高于I型肌原纤维,且II型肌纤维自身电子密度不均,排列扭曲。对照组II型肌纤维没有以上相应改变。结论：糖皮质激素具有诱导肌萎缩的作用,可引起局部及全身的肌肉均萎缩,其肌肉细胞最大直径减小,细胞数目减少,且影响II型肌原纤维的分布与排列。
|
| 关 键 词： | 糖皮质激素类 臀肌 肌萎缩 肌纤维 电子密度 |
Effect of Glucocorticoid Local Injection on Rabbit Muscle Tissues |
| |
| Su Lianshu,Zhang Zheng,Wang Guangxun,et al.. Effect of Glucocorticoid Local Injection on Rabbit Muscle Tissues[J]. Chinese Journal of Surgery of Integrated Traditional and Western Medicine, 2011, 17(4): 365-368. DOI: 10.3969/j.issn.1007-6948.2011.04.010 |
| |
| Authors: | Su Lianshu Zhang Zheng Wang Guangxun et al. |
| |
| Affiliation: | Su Lianshu,Zhang Zheng,Wang Guangxun,et al.Dept.of Orthopedic Surgery,Tianjin Medical University Baodi Clinical College,Tianjin,(301800),China |
| |
| Abstract: | Objective To investigate the morphologic effect and histological changes of gluteal muscle by glucocorticoid intramuscular injection.Methods Twenty-four healthy adult rabbits were selected and randomly assigned into two groups with twelve rabbits each:normal control group and test group.Each rabbit was tested as auto-control on one side gluteal muscle in the experimental group.Parts of the gluteal muscles were sliced up and dyed with hematoxylin-eosin staining(HE).The slide was observed under light microsco... |
| |
| Keywords: | glucocorticoid gluteal muscle atrophy muscle fiber electron density |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
