| 替比夫定治疗HBeAg阳性慢性乙型肝炎53例 |
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| 引用本文： | 李勇年,刘淮阳,吴炜强,翟佩任,燕青松,那军,魏丽军,高建兴,郭晏海. 替比夫定治疗HBeAg阳性慢性乙型肝炎53例[J]. 西北国防医学杂志, 2011, 32(3): 176-178 |
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| 作者姓名： | 李勇年 刘淮阳 吴炜强 翟佩任 燕青松 那军 魏丽军 高建兴 郭晏海 |
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| 作者单位： | 1. 解放军323医院感染科,陕西,西安,710054
2. 第四军医大学药学系基因研究所 |
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| 摘 要： | 目的:分析替比夫治疗HBeAg阳性慢性乙型肝炎的临床疗效.方法:考察53例替比夫定治疗HBeAg阳性慢性乙型病毒性肝炎患者的临床表现、生化学、病毒学和病毒基因耐药情况.结果:HBV DNA不可测率、ALT复常率、HBeAg消失率、HBeAg血清转换率和基因型耐药率分别为66.0%、83.7%、73.6%、13.2%和9...
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| 关 键 词： | 慢性乙型肝炎 替比夫定 核苷类似物 |
Clinical effect of telbivudine in 53 patients with HBeAg - positive chronic hepatitis B |
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| LI Yong-nian,LIU Huai-yang,WU Wei-qiang,et al.. Clinical effect of telbivudine in 53 patients with HBeAg - positive chronic hepatitis B[J]. Medical Journal of National Defending Forces in Northwest China, 2011, 32(3): 176-178 |
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| Authors: | LI Yong-nian LIU Huai-yang WU Wei-qiang et al. |
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| Affiliation: | LI Yong-nian,LIU Huai-yang,WU Wei-qiang,et al.(Department of Infectious Diseases and Liver Unit,323 Hospital of PLA,Xi'an 710054,China) |
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| Abstract: | Objective:To evaluate the clinical effect of telbivudine in patients with HBeAg-positive chronic hepatitis B(CHB).Methods: The level of serum alanine aminotransferase(ALT),HBV DNA,HBeAg loss,HBeAg seroconversion and genotype resistance of 53 patients with HBeAg-positive treated with telbivudine were compared.The average course of treatment was 22.2 months.Results:The rates of serum undetectable HBV DNA,normalization of ALT,HBeAg loss,HBeAg seroconversion and genotype resistance were 66.0%,83.7%,73.6%,13.2% ... |
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| Keywords: | Chronic hepatitis B Telbivudine Nucleoside/nucleotide analogue |
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