| 肝纤维化形成过程中大鼠血清中胰岛素样生长因子结合蛋白-2的动态变化 |
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| 引用本文： | 申凤俊,赵彩霞,唐瑾.肝纤维化形成过程中大鼠血清中胰岛素样生长因子结合蛋白-2的动态变化[J].山西医科大学学报,2011,42(7):532-534,611. |
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| 作者姓名： | 申凤俊 赵彩霞 唐瑾 |
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| 作者单位： | 山西医科大学第一临床医学院消化科,太原,030001 |
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| 摘 要： | 目的观察大鼠肝纤维化形成过程中胰岛素样生长因子结合蛋白-2(IGFBP-2)的动态变化,探讨IGFBP-2与肝纤维化的关系。方法将36只大鼠随机分为2组:正常对照组6只(n=6),模型组30只(n=30)。除正常对照组外,给予大鼠40%CCl4皮下注射,每周2次,共计8周。正常对照组给予相同剂量的油剂皮下注射。模型组在开始注射CCl4后的第2、4、6、8周末分别处死大鼠6只。测定肝功能(ALT)、门静脉压,对肝组织进行常规HE与Masson三色染色,对血清中IGFBP-2采用酶联免疫法测定,并将其与肝纤维化程度进行相关分析。结果与正常对照组比较,2、4、6、8周模型组大鼠血清IGFBP-2水平增高(P<0.01)。模型组大鼠随着造模时间的延长,肝纤维化程度的加重,门静脉压逐渐增高,血清中IGFBP-2的水平逐渐增高,且IGFBP-2水平与肝纤维化程度呈正相关(r=0.874 2,P<0.001)。结论在肝纤维化形成过程中,血清中IGFBP-2的水平逐渐增高,提示其可能与肝纤维化有关。
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| 关 键 词： | 肝纤维化 肝功能 门静脉压 IGFBP-2 |
Dynamic alteration of insulin-like growth factor binding protein-2 in fibrotic rat liver |
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| SHEN Feng-jun,ZHAO Cai-xia,TANG Jin.Dynamic alteration of insulin-like growth factor binding protein-2 in fibrotic rat liver[J].Journal of Shanxi Medical University,2011,42(7):532-534,611. |
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| Authors: | SHEN Feng-jun ZHAO Cai-xia TANG Jin |
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| Institution: | SHEN Feng-jun,ZHAO Cai-xia,TANG Jin (Dept of Gastroenterology,First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China) |
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| Abstract: | Objective To investigate the dynamic changes of insulin-like growth factor binding protein-2(IGFBP-2) during the development of liver fibrosis and to explore the association between IGFBP-2 and liver fibrosis. Methods Thirty-six Wistar rats were randomly allocated into normal group(n=6) and model group(n=30).Rats were given intraperitoneal injection of 40% CCl4 twice a week,totally for 8 weeks to induce the liver fibrosis in model group,while in control group the rats were subcutaneously injected with the s... |
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| Keywords: | IGFBP-2 |
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