重型肝炎合并革兰阴性菌感染的预后及影响因素

目的 探讨重型肝炎合并革兰阴性菌感染的预后及影响因素,为有效防治提供指导.方法 回顾性分析2004年1月-2006年6月我院住院的重型病毒性肝炎合并革兰阴性菌感染220例的预后,以及性别、年龄、肝炎型别、各种其他合并症、感染部位及细菌类型对预后的影响.结果 重型肝炎合并革兰阴性菌感染占总体细菌感染的79.1%,总病死率...

Prognosis and prognostic factors of severe hepatitis with gram-negative bacterial infection

Objective To investigate the prognosis and prognostic factors of severe hepatitis with gram-negative bacterial in-fection so as to provide guidance for its effective prevention and treatment.Methods A retrospective analysis was made of the prognosis of 220 cases of severe viral hepatitis with gram-negative bacterial infection,who were admitted to our hospital from Jan.2004 to Jun.2006,and the influence of sex,age,type of severe hepatitis,complications,the sites of infection and species of bacteria on the pronosis.Results The severe hepatitis patients with gram-negative bacterial infection accounted for 79.1% among the pa-tients with bacterial infections and the mortality rate was 55.6%.The patients aged more than 50 years had the highest mortality rate.There were no significant differences in the mortality rates among the patients with acute severe hepatitis,subacute severe hepa-titis and chronic severe hepatitis.The patients with blood infection had a more increased mortality rate compared with those with res-piratory infection.The patients with Escherichia coli infection had higher mortality rate than those with Klebsiella and Pseudomonas aeruginosa infections.Conclusions The severe hepatitis patients with gram-negative bacterial infection have poorer prognosis.The high-risk patients should be paid much attention and provided with active treatment modalities to improve the survival rate.