发热伴血小板减少综合征病例中无形体病鉴别诊断与治疗

目的 确定发热伴血小板减少综合征患者中是否存在人粒细胞无形体病(human granulocytic anaplasmosis,HGA),并进行HGA临床分析.方法 将2010年收治的42例发热伴血小板减少综合征患者血液标本,送中国疾病预防控制中心(Centers for Disease Control and Pre...

Differential diagnosis and treatment of human granulocytic anaplasmosis in patients with fever and thrombocytopenia syndrome

Objective To ensure whether human granulocytic anaplasmosis(HGA) occur in patients with fever and thromobo-cytopenia syndrome and to analyze the clinical data of the HGA patients.Methods Serum samples were collected from 42 patients with fever and thromobocytopenia syndrome,treated in our hospital in 2010,in acute stage and recovery stage,respectively,and sent to Chinese Centers for Disease Control and Prevention(CDC) for detection of IgG antibodies.Some DNA samples were tested by nested PCR targeting the 16S rRNA gene in Shandong Province CDC.Clinical features of the laboratory-confirmed HGA patients were analyzed.Results Diagnosis of HGA was confirmed in 5 patients through serological testing and in 2 patients by PCR,one of whom was found to be"new Bunia virus" antibody positive.Conclusions HGA may occur in the patients with fever and throm-bocytopenia syndrome.The two kinds of diseases should be distinguished and treated with proper antibiotics.