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| 银杏叶提取物对运动大鼠肌膜Na+,K+-ATP酶活性的影响 | |
| 引用本文： | 刘庆山,盛蕾,王秋娟,杜冠华.银杏叶提取物对运动大鼠肌膜Na+,K+-ATP酶活性的影响[J].中国药学杂志,2006,41(22):1703-1705. |
| 作者姓名： | 刘庆山 盛蕾 王秋娟 杜冠华 |
| 作者单位： | 1. 中国医学科学院-中国协和医科大学药物研究所,北京,100050;中国药科大学,南京,210009 2. 江苏省体育科学研究所,南京,210014 3. 中国药科大学,南京,210009 4. 中国医学科学院-中国协和医科大学药物研究所,北京,100050 |
| 基金项目： | 国家自然科学基金;江苏省体育局资助项目 |
| 摘 要： | 目的为研究银杏叶提取物(EGb761)对大鼠大强度跑台运动及其肌膜Na+,K+-ATP酶活性的影响。方法采用大强度上坡跑大鼠运动模型,测定运动力竭时间、Na+,K+-ATP酶、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)活性、谷胱甘肽含量、总抗氧化能力、丙二醛(MDA)水平。结果EGb761可以提高大鼠大强度运动至力竭的时间,并使单次定量运动后即刻白肌肌膜总抗氧化能力(TAOC)和谷胱甘肽含量(GSH)升高、MDA水平下降。结论EGb761可能通过直接和间接途径清除大强度常规训练时产生的自由基,保护肌膜Na+,K+-ATP酶,提高训练效果,延长运动时间;明显提高单次定量运动后即刻GSH,TAOC,降低肌膜MDA水平。 |
| 关 键 词： | 银杏叶提取物 大强度运动模型 肌膜 Na+ K+-ATP酶活性 |
| 文章编号： | 1001-2494（2006）22-1703-04 |
| 收稿时间： | 2005-10-11 |
| 修稿时间： | 2005-10-11 |
Effects of EGb761 on Activity of Sarcolemma's Na + ,K+-ATPase in Strenuous Exercise Rats |
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| LIU Qing-shan,SHENG Lei,WANG Qiu-juan,DU Guan-hua.Effects of EGb761 on Activity of Sarcolemma''s Na + ,K+-ATPase in Strenuous Exercise Rats[J].Chinese Pharmaceutical Journal,2006,41(22):1703-1705. | |
| Authors: | LIU Qing-shan SHENG Lei WANG Qiu-juan DU Guan-hua |
| Institution: | 1. Institute of Materia Medica, Chinese Academy of Medical Sciences-Peking Union Medical College, Beifing 100050, China ; 2. China Pharmaceutical University, Nanjing 210009, China ; 3. Institute of Sport Science of Jiangsu Province, Nanjing 210014, China |
| Abstract: | OBJECTIVE To investigate the effects of EGb761(extracts of Ginkgo biloba 761) on Na~ ,K~ -ATPase activity of rats immediately after running on treadmill.METHODS High intensity running up-grade train model was selected.The exhausitive exercise time and activity of Na~ ,K~ -ATPase,SOD,GPx,GSH,TAOC and MDA were determined.RESULTS The activity of sarcolemma Na~ ,K~ -ATPase of rats was increased significantly.The contents of GSH,TAOC(Total anti-oxidative content) were increased,while MDA was decreased.CONCLUSION EGb761 protects the activity of Na~ ,K~ -ATPase by eliminating free radicals in strenuous exercise rats.The contents of GSH,TAOC are enhanced,and the content of MDA is decreased dose-dependently. |
| Keywords: | extracts of Ginkgo biloba 761 strenuous exercise sarcolemma Na~ K~ -ATPase |
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