北京降压零号与苯那普利对高血压患者血糖和血脂代谢的影响对比研究

目的观察北京降压零号对高血压患者血糖和血脂代谢的影响和降压疗效。方法将200例按WHO标准选择非肥胖轻中度高血压患者随机分为两组。北京降压零号治疗组:每日服北京降压零号1片;苯那普利组:每日服苯那普利10mg,均为每日清晨8时1次口服,疗程12月。治疗前后测血压、空腹及餐后2h血糖及胰岛素,计算胰岛素敏感指数(ISI),血脂。并设正常对照组。结果两组血压均明显下降(P<0.01),组间无差异(P>0.05);治疗前后各组血脂无明显差异,治疗后各组空腹血糖无明显差异,两组餐后2h血糖、空腹及餐后2h胰岛素显著升高(P<0.01),ISI显著降低(P<0.01)。治疗后上述指标显著改善(P<0.01),且与正常对照组比较无显著性差异(P>0.05);不良反应组间比较无显著性差异(P>0.05)。结论北京降压零号和苯那普利都能改善高血压胰岛素抵抗,对血脂无影响。

Research on Comparision of Beijing Hypertension NO.0 and Benazepril on Glucose Tolerance and Lipid metabolism in patient of essential hypertension

OBJECTIVE To observe the effect of Beijing Hypertension NO.0 benazepril(BHN) on Glucose Tolerance,Lipid metabolism and Antihypertension in patient of essential hypertension.METHODS 200 cases with mild to moderate EH which were not obesity were divided randomly in 2 group,Beijing Hypertension NO.0 treatment group(BHN),patient received Beijing Hypertension NO.0 one pill qm for 12 months,benazepril group(BE),patient received benazepril 10mg qm for 12 months.The fasting and 2-hour postprandial serum glouse(SG)and insulin level were measured and the insulin sensitivity index(ISI) was caculated before and after the treatment,BP and blood lipid were measured together.healty person were observed control.RESULTS Beijing Hypertension NO.0 and benazepril could decrease the blood pression significantly(P<0.01),There was no obvious difference of blood pression in two groups(P>0.05).There was no obvious difference in lipidand fasting glucose between two group before and after treatment.Two group 2-hour postprandial,fasting glucose and insulin level increased significantly(P<0.01),ISI was lowered clearly.There was no distinctly difference between two groups and healthy control group(P>0.05);there was no difference in disadvantage reaction between two groups(P>0.05).CONCLUSION The result suggest that Beijing Hypertension NO.0 and Benazepril could improve insuline resistance in hypertensive patients.They had no effects on lipid metabolism.