Survivin与p53的组合在卵巢上皮性癌早期诊断中的意义

目的 探讨Survivin与p53在卵巢上皮性癌诊断中的意义。方法 采用免疫组化方法检测Sur—vivin及p53蛋白在57例卵巢上皮性囊腺癌和19例卵巢上皮性良性肿瘤组织中的表达。结果 Survivin基因在卵巢上皮性良性肿瘤细胞内无表达，在恶性肿瘤的表达率为42．1％。p53在卵巢上皮性良、恶性肿瘤细胞中的表达率分别为26．3％、56．1％。Survivin基因表达与临床分期、组织学类型无相关性（P〉0．05），与良、恶性有关（P〈0．05）。p53蛋白的表达与卵巢上皮性癌的临床分期以及良、恶性有相关性。p53蛋白与Survivin的阳性表达率有显著性差异（P〈0．01）。结论 Survivin基因在卵巢上皮性良性与恶性肿瘤的表达有差异，与临床分期、组织学类型无关。p53蛋白的表达与临床分期及良、恶性均有相关性。Survivin与p53在卵巢上皮性癌的表达有显著相关性。

Diagnostic Significance of Survivin Associated with p53 in Ovarian Epithelial Carcinoma

Objective To study the expression in ovarian epithelial benign tumor and ovarian epithelial carcinoma,and relationship and the diagnostic significance of Survivin and p53 expression in Ovarian Epithelial Carcinoma.Methods To examine the expression of Survivin and p53 protein in 57 ovarian epithelial cancer and 19 benign tumors using immunohitochemical method.Results The expression of Survivin in ovarian epithelial benign tumor is 0 and the expressive ratio in the cancer is 42.1%.The expressive rate of p53 in ovarian epithelial benign tumor and ovarian epithelial cancer is 26.3% and 56.1%.There was no relationship between Survivin gene expression and FIGO stage,pathological grade(P>0.05).There is relationship between benign and cancer.The expression of p53 has relationship between FIGO stage,benign and cancer.There are intimate relationship between Survivin gene expression and p53 (P<0.01).Conclusion Survivin gene expressions were different between ovarian epithelial benign tumor and ovarian epithelial carcinoma.There was no relationship between Survivin gene expression and FIGO stage,pathological grade.The expression of p53 has relationship between FIGO stage,benign and cancer.There was significant relationship between Survivin gene expression and p53.