慢性肾脏病碱性磷酸酶与甲状旁腺素相关性分析

目的探讨慢性肾脏病（CKD）患者血清碱性磷酸酶（ALP）与甲状旁腺素（PTH）的相关性，并评估两者在肾性骨病（ROD）诊断及治疗中的意义。方法选择CKD3—5期患者60例，均抽取空腹静脉血，分别测定ALP及PTH，进行相关性分析。结果当PTH〉300pg／ml时，ALP与PTH相关性良好，且呈正相关，有统计学意义（r=0．865，P〈0．05）；当PTH≤300pm／dl时，ALP与PTH无相关性。结论ALP与PTH相关性良好，随着PTH的增高，ALP增高越明显。两者结合，对诊断和治疗高转运骨病（HTO）有重要的临床价值。且ALP检测方法简单，花费少。

The Correlation Analysis of Alkaline Phosphatase and Parathyroid Hormone in Chronic Kidney Disease

Objective To explore the correlation analysis of alkaline phosphatase（ALP） and parathyroid hormone（PTH） in chronic kidney disease（CKD）, and evaluate their significance in diagnosis and treatment of renal osteodystrophy（ROD}. Methods 60 CKD3-5 stage patients were extracted of fasting venous Mood, to determinate ALP and PTH and analysis their correlation. Results ALP and PHT showed a significant positive correlation when PTH〉300pg/ml（r=0.865, P〈0.05）; they were no correlation when PTH ≤300pm/dl. Conclusion ALP and PTH correlated well, and with the increase of PTH, ALP increased more obviously. They have important clinical value in diagnosis and treatment for high turnover osteodystropy（HTO）. The detection method for ALP was simple and low cost.