DM2肾病患者血清leptin水平与红细胞ATP酶活性的关系

目的：探讨了2型糖尿病（DM2）肾病患者血清瘦素（leptin）水平与红细胞膜Na＋K＋-ATP酶和Ca2＋Mg2＋-ATP酶活性改变参与DM2肾病发生的可能机制。方法：应用放射免疫分析和Reilni制膜法测定了40例DM2无肾病和32例DM2肾病患者血清leptin水平和红细胞膜Na＋K＋-ATP酶和Ca＋2Mg＋2-ATP酶含量,并与35名正常健康人作比较。结果：DM2无肾病组和肾病组血清leptin水平非常显著地高于正常人组（P〈0.01）和红细胞膜Na＋K＋-ATP酶和Ca2＋Mg2＋-ATP酶水平显著地低于正常人组（P〈0.01）。DM2肾病组与无肾病组亦有显著性差异（P〈0.05）。结论：DM2的发生、发展与血清leptin水平和红细胞膜Na＋K＋-ATP酶和Ca2＋Mg2＋-ATP酶的活性有密切的关系。

Relationship Between Serum Leptin Level, ATPase Activity of Erythrocyte Membrance and Development of Diabetic Nephropathy in Patients with DM2

Objective To study the possible mechanism of dovelopment of nephrosis affected by changes of serum leptin levels and alteration of activities of Na＋K＋-ATPase and Ca2＋Mg2＋-ATPase of erythrocyte membrane in patients with type 2 diabetes（DM2）.Methods Serum leptin levels（with RIA） and erythrocyte membrane Na＋K＋-ATPase and Ca2＋Mg2＋-ATPase activitities（with Reinila method） were determined in 40 DM2 patients without nephropathy,32 DM2 patients with nephropathy and 35 controls.Results Serum leptin levels were significantly higher in the diabetics as a whole than those in controls（P〈0.01）,while the RBC Na＋K＋-ATPase and Ca2＋Mg2＋-ATPase activities were significantly lower（P〈0.01）.Among the diabetic patients,the serum leptin levels in patients without nephrosis（P〈0.05）,but the RBC membrance ATPase activities were significantly lower（P〈0.05）.Conclusion Development of type 2 diabetes nephrosis might be correlated with the high serum leptin level and decreased ATPase activities of erythrocite membrane.