肠易激综合征的中医虚实证型与血浆脑肠肽水平变化的相关性研究

目的]观察肝郁气滞型、脾胃虚弱型、肝郁脾虚型肠易激综合征（IBS）患者脑肠肽的变化,探讨IBS的中医虚实证型与血浆脑肠肽水平变化的相关性。方法]90例IBS患者分为肝气郁滞证组、肝郁脾虚证组、脾胃虚弱证组各30例,正常对照（正常）组10例,应用放射免疫法同批测定血浆血管活性肠肽（VIP）、神经肽Y（NPY）和神经降压素（NT）水平。结果]3个证型组患者血浆VIP水平显著高于正常组（P〈0.05,〈0.01）;脾胃虚弱、肝郁脾虚证组患者VIP水平显著高于肝气郁滞证组（P〈0.05）,但脾胃虚弱证组和肝郁脾虚证组之间比较差异无统计学意义。3个证型组患者血浆NPY水平显著低于正常组（P〈0.05,〈0.01）,肝郁脾虚证组和肝气郁滞证组NPY水平明显低于脾胃虚弱证组（P〈0.01,〈0.05）,肝郁脾虚证组NPY水平低于肝气郁滞证组,但2组比较差异无统计学意义。3个证型组患者血浆NT水平显著高于正常组（P〈0.01）。3证型间比较差异无统计学意义。结论]不同中医证型IBS脑肠肽存在不同的变化。IBS的中医病机观与现代医学所倡导的脑-肠轴学说具有相关性。

Correlation between TCM deficiency and excess syndrome and plasma brain-gut peptides levels in patients with irritable bowel syndrome

Objective]To observe the change of the plasma brain-gut peptides levels about syndrome type of stagnation of qi due to depression of the liver,spleen stomach deficiency and liver-qi stagnation and spleen-qi deficiency in patients with irritable bowel syndrome(IBS),and to probe into the correlation correlation between TCM fullness and deficiency syndrome type of and plasma brain-gut peptides levels.Methods]Ninety cases of patients with IBS were devided into stagnation of qi due to depression of the liver g...