| 卡托普利和纳多洛尔对高血压病患者肾血流动力学的影响 |
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| 引用本文： | 龚培力,陈汇,朱忠华,安锐,曾繁典. 卡托普利和纳多洛尔对高血压病患者肾血流动力学的影响[J]. 中国新药与临床杂志, 1993, 0(6) |
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| 作者姓名： | 龚培力 陈汇 朱忠华 安锐 曾繁典 |
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| 作者单位： | 同济医科大学临床药理研究室，同济医科大学临床药理研究室，同济医科大学附属协和医院，同济医科大学附属协和医院，同济医科大学临床药理研究室 武汉 430030，武汉 430030 |
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| 摘 要： | 原发性高血压30例随机分为卡托普利(37.5-75mg/d, po, 共4wk)和纳多洛尔(40-80mg/d, po,共4wk)2组,各15例。结果:2药均使血压显著降低(P<0.01);对肾血流量和肾小球滤过率均无明显改变,但均使肾血流量/心输出量增高和肾血管阻力降低(P<0.01,P<0.05)。提示2药可能通过直接扩张肾血管而维持肾循环,有益于高血压病的长期治疗。
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| 关 键 词： | 卡托普利 纳多洛尔 高血压 血流动力学 肾循环 |
Effects of captopril and nadolol on renal hemodynamics in the patients with essential hypertension |
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| GONG Pei-Li,CHEN Hui,ZHU Zhong-Hua,AN Rui ZENG Fan-Dian. Effects of captopril and nadolol on renal hemodynamics in the patients with essential hypertension[J]. Chinese Journal of New Drugs and Clinical Remedies, 1993, 0(6) |
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| Authors: | GONG Pei-Li CHEN Hui ZHU Zhong-Hua AN Rui ZENG Fan-Dian |
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| Affiliation: | GONG Pei-Li,CHEN Hui,ZHU Zhong-Hua1,AN Rui1 ZENG Fan-Dian |
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| Abstract: | Thirty patients with essential hypertension were randomized into 2 groups. Fifteen patients were treated with captopril 37.5-75 mg/d, po and the other 15 patients were treated with nadolol 40-80 mg/d, po, all for 4 wk. Results showed that both drugs had similar hypotensive effects (P<0. 01) and no obvious effects on renal blood flow and glomerular filtration rate. But the ratio of renal blood flow to cardiac output all rose (P< 0. 01) , whereas the renal vascular resistance all decreased (P< 0. 05) . These findings suggest that both drugs may act via a direct intrarenal vasodilator mechanism and then maintain the renal circulation. This effect contributes advantages in long-term therapy of patients with hypertension. |
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| Keywords: | captopril nadolol hypertension hemodynamics renal circulation |
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